Effects of fibroblast transplantation into the internal pallidum on levodopa-induced dyskinesias in parkinsonian non-human primates  

作　　者：Arun Singh Claire A.Gutekunst Subramaniam Uthayathas John P.M.Finberg Klaus Mewes Robert E. Gross Stella M.Papa Yair Feld 

机构地区：[1]Neuropharmacology and Neurologic Diseases,Yerkes National Primate Research Center [2]Department of Neurosurgery,Emory University School of Medicine [3]Molecular Pharmacology Department,Rappaport Faculty of Medicine [4]Department of Neurology,Emory University School of Medicine [5]Gene Grafts Ltd

出　　处：《Neuroscience Bulletin》2015年第6期705-713,共9页神经科学通报（英文版）

基　　金：supported by grants from the National Institutes of Health (NS045962, NS073994, NCRR RR000165 and ORIP/OD OD011132);Forum Pharmaceuticals, Inc.;Gene Graft, Ltd

摘　　要：Recent studies have shown that fibroblast transplantation can modify the activity of basal ganglia networks in models of Parkinson＇s disease. To determine its effects on parkinsonian motor symptoms, we performed autologous dermal fibroblast transplantation into the internal pallidum （GPi） in two parkinsonian rhesus monkeys with stable levodopa- induced dyskinesias （LIDs）. Levodopa responses were assessed every week after transplantation for three months. A reduction of between 58% and 64% in total LIDs on the contralateral side was observed in both animals. No clear LID changes were observed on the ipsilateral side. These effects lasted the entire 3-month period in one monkey, but declined after 6-8 weeks in the other. The antiparkinsonian effects of levodopa did not diminish, The results of this pilot study indicate that fibroblast transplantation into the GPi may have beneficial effects on LIDs and warrant further investigation for potential therapeutic use.Recent studies have shown that fibroblast transplantation can modify the activity of basal ganglia networks in models of Parkinson＇s disease. To determine its effects on parkinsonian motor symptoms, we performed autologous dermal fibroblast transplantation into the internal pallidum （GPi） in two parkinsonian rhesus monkeys with stable levodopa- induced dyskinesias （LIDs）. Levodopa responses were assessed every week after transplantation for three months. A reduction of between 58% and 64% in total LIDs on the contralateral side was observed in both animals. No clear LID changes were observed on the ipsilateral side. These effects lasted the entire 3-month period in one monkey, but declined after 6-8 weeks in the other. The antiparkinsonian effects of levodopa did not diminish, The results of this pilot study indicate that fibroblast transplantation into the GPi may have beneficial effects on LIDs and warrant further investigation for potential therapeutic use.

关 键 词：globus pallidum AUTOLOGOUS LEVODOPA antiparkinsonian MONKEYS 

分 类 号：R742.5[医药卫生—神经病学与精神病学]