苯骈呋喃类衍生物的合成及促骨形成作用  

Synthesis of benzofuran derivatives and their effect on promoting bone formation

作　　者：李瑞鹏[1] 郭丽[1] 郑虎[1] 齐庆蓉[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2015年第6期631-634,共4页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目(批准号:81130026)

摘　　要：目的设计并合成苯骈呋喃类衍生物,并研究其促骨形成作用。方法以苯甲醚为原料,经7步反应得到目标产物,并研究目标产物的促骨形成作用。结果目标化合物的结构经1HNMR、MS确证。结论目标化合物Ⅱa具有较好的促骨形成作用。OBJECTIVE To design and synthesize benzofuran derivatives and to evaluate their effect on promoting bone formation. METHODS The target compounds were synthesized via seven steps using anisole as the starting material, and the promotion test of bone formation had been carried. RESULTS The target compounds were obtained, and the chemical structures were confirmed by 1HNMR and MS. CONCLUSION Target compound Ⅱa was effective on promoting the bone formation.

关 键 词：雷洛昔芬 苯骈呋喃 衍生物 设计 合成 选择性雌激素受体调节剂 促骨形成 活性 

分 类 号：R914[医药卫生—药物化学]