Embryotoxicity and Teratogenicity of Rhein  

作　　者：Yanchun Hu Chaorong Zeng Fei Liao Hui Tan Lei Wu Xi Liu Zhicai Zuo Junliang Deng Anchun Cheng Yahui Wei 

机构地区：[1]College of Veterinary Medicine, Sichuan Agricultural University, Ya 'an 625014, China [2]Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu 611130,China [3]The Second People's Hospital of Yucheng District, Ya 'an 625000, China [4]Key Laboratory of Resource Biology and Biotechnology in Western China, School of Life Science, Northwest University, Xi 'an710069, China

出　　处：《Journal of Health Science》2014年第4期180-184,共5页健康科学（英文版）

摘　　要：To study the effect ofrhein on embryo development of rats and fetuscs, the SD rats were divided into rhein （87.5, 175 and 350 mg/kg） group and negative control group treated with 0.5% CMC （carboxyl methyl cellulose）. The rats were administrated with rhein daily for 10 days from 6th to 15th day after pregnancy. The pregnancy rats were dissected at 20th day after pregnancy. The total weight of the fetuses, the number of corpus luteum, plant gland, absorbed fetus, live fetus, dead futus, monsters, body weight, body height and tail length were recorded. Compared with the control group, rhein group occurred with the administration of toxicity-related clinical symptoms. The changes in weight increase related with the amount ofrhein （P 〈 0.05） and the increased number of absorbed fetuses in each rhein group （P 〈 0.05） were presented. Obvious differences occurred in the rhein groups in terms of the incidence of visceral abnormalities, each organ abnormalities and fossa malformations, etc. （P 〈 0.05）. Compared with the control group, there was no significant difference in the low-dose group by fetal rat bone examination （P 〉 0.05）, while the remaining dose groups manifested various bone deformities such as sternum sections missing, incomplete ossification of the skull and thoracic vertebrae separation or deformation, which was obviously different from the control group （P 〈 0.01）. Rhein had a significant effect on the reproductive function of pregnant rats. It can even result in the bones＇ and internal organs＇ dysplasia of fetal rats. Rhein has a significant teratogenic effect in rats.

关 键 词：RHEIN EMBRYOTOXICITY teratogenicity. 

分 类 号：R161[医药卫生—公共卫生与预防医学]