TERT启动子突变与继发性胶质母细胞瘤病人生存预后的相关性分析  

Correlation analysis between TERT promoter mutation and clinical outcome in secondary glioblastomas

作　　者：李瑞[1] 李海林[1] 林宁[1] 尤永平[1] 颜伟[1] 

机构地区：[1]南京医科大学第一附属医院神经外科,210029

出　　处：《中国微侵袭神经外科杂志》2015年第12期532-534,共3页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：国家自然科学基金青年基金项目(编号:81402056;81402068)

摘　　要：目的分析端粒酶逆转录酶(telomerase reverse transcriptase,TERT)启动子突变在继发性胶质母细胞瘤中与病人生存预后的相关性。方法通过巢式PCR和Sanger测序检测15例继发性胶质母细胞瘤样本中TERT启动子突变状态,分析TERT启动子突变在继发性胶质母细胞瘤中的发生频率,应用Kaplan-Meier生存曲线分析TERT启动子突变与病人无进展生存期及总生存期的关系。结果 6例(6/15,40%)继发性胶质母细胞瘤样本存在TERT启动子突变,携带TERT启动子突变的胶质母细胞瘤病人较TERT启动子野生型病人有相对更长的总生存期(P=0.0496),然而差异显著性处于临界状态。此外,TERT启动子突变和胶质母细胞瘤病人无进展生存期关系并不确切(P=0.2489)。结论 TERT启动子突变在继发性胶质母细胞瘤中稳定存在,并可作为病人总生存期潜在预测标志物。Objective To analyze the correlation of telomerase reverse transcriptase（TERT） promoter mutation with clinical outcome of secondary glioblastomas（SGs）. Methods Total 15 SGs were assessed by nested PCR and Sanger sequencing for TERT promoter mutation status and analyzing the frequency of occurrence of the mutation in SGs. The correlation of the mutation with progression-free and overall survivals were analyzed using Kaplan-Meier survival curves. Results TERT promoter mutation was detected in 6（6/15, 40%） SGs.Kaplan-Meier survival analysis revealed a marginally significant association between TERT promoter mutation and a longer overall survival in TERT promoter mutation（P = 0.0496）. However, the association of TERT promoter mutation and progression free survival remained to be elucidated in a larger cohort（P = 0.2489）. Conclusion TERT promoter mutation is prevalent and has significant prognostic value in SGs.

关 键 词：胶质母细胞瘤 继发性 TERT启动子 突变 总生存期 

分 类 号：R739.4[医药卫生—肿瘤]