可兴奋细胞胞吐胞吞的耦联机制  

The Coupling Mechanism of Exocytosis and Endocytosis in the Excitable Cells

作　　者：刘彦梅 郑晓璐 袁天一 陈良怡[1] 

机构地区：[1]生物膜与膜生物工程国家重点实验室北京大学分子医学研究所,北京100871

出　　处：《中国细胞生物学学报》2015年第12期1606-1615,共10页Chinese Journal of Cell Biology

基　　金：国家重点基础研究发展计划(批准号:2013CB531200);国家自然科学基金(批准号:81222020;31221002;31327901;31570839和31301186)资助的课题~~

摘　　要：调节型胞吐存在于神经元、内分泌细胞和外分泌细胞等可兴奋细胞以及免疫细胞等特化细胞中,是复杂而精确调节的分泌过程。其作用广泛,与神经信号传递、激素释放、免疫反应等重要的生理活动密切相关。调节型胞吐发生后,在分秒的时间尺度上,可兴奋性细胞快速启动与胞吐发生位置密切相关的调控型胞吞,回收细胞膜脂质和囊泡的膜蛋白,迅速清除分泌位点上由于胞吐而留下的蛋白以利于下一轮的分泌,回收并填充可释放囊泡库,维持细胞膜的平衡。该文先分别介绍可兴奋细胞中胞吐和胞吞的主要模式,然后探讨了它们之间耦联的机制。Regulative exocytosis, existing in the excitable cells including neurons, endocrine cells and exocrine cells, is precisely regulated and mediates important physiological activities such as neurotransmittersand hormones release. Following exocytosis, coupled endocytosis occurs within seconds to minutes at spatially correlated sites to retrieve vesicular membrane and proteins on the plasma membrane. The rapid clearance of the vesicle membrane and protein from the exocytic sites will facilitate the next round exocytosis of vesicles at the release sites, balance of surface membrane homeostasis and secretory vesicles recycling. Here we review different modes of exocytosis and endocytosis, and explore the mechanisms of spatiotemporal exo-endocytosis coupling based on the current knowledge and our recent experimental data.

关 键 词：胞吐 胞吞 耦联 可兴奋细胞 网格蛋白 

分 类 号：R346[医药卫生—基础医学]