175例连花清瘟胶囊致药品不良反应/事件的文献分析  

Literature Analysis of Clinical Application and Adverse Drug Reaction/Event of Lianhua Qingwen Capsule

作　　者：彭丽丽[1] 李岚[1] 沈璐[1] 李馨龄[1] 

机构地区：[1]国家食品药品监督管理总局药品评价中心,北京100045

出　　处：《中国药物警戒》2015年第12期753-755,759,共4页Chinese Journal of Pharmacovigilance

摘　　要：目的对连花清瘟胶囊的不良反应/不良事件发生情况进行文献分析,为临床合理用药提供参考。方法在中国知网(CNKI)、万方医学网数据库中检索近10年发表的涉及连花清瘟胶囊不良反应的文献报道,采用循证医学和情报学原理,对检得的连花清瘟胶囊不良反应文献进行筛选和分析。结果研究纳入文献38篇,涉及病例175例;不良反应多发生在首次服药后,主要累及胃肠系统(73.9%)和皮肤及其附件(9.6%)等,主要表现为恶心、呕吐、腹胀、腹泻、皮疹、瘙痒等。结论应加强连花清瘟胶囊在临床使用过程中的应用监测,规范和完善连花清瘟胶囊的药品说明书,以促药品的合理应用,保证患者用药安全。bjective To investigate and analyze the literatures on clinical Lianhua Qingwen Capsule to provide reference for its rational use in clinic. of Lianhua Qingwen Capsule were retrieved in the databases of CNKI,W application and ADR/ADE induced by Methods The literatures for ADR/ADE angfang data for the last 10 years, which were screened out and analyzed by evidence-based medicine method and bibliometric statistical method. Results Thirty-eight literatures were included and toltal 122 adverse drug reaction cases were collected. Most drug adverse reactions occurred after first use, primarily involved gastrointestinal system（73.9%）, skin and its appendaes （9.6%）, including nausea, vomiting, abdominal distention, diarrhea, skin rashes, itching, etc. Conclusion We should reinforce the clinical apphcation of Lianhua Qingwen Capsule, standardize and improve the drug package inserts, promote the rational use of drug and guarantee the safety of patients.

关 键 词：连花清瘟胶囊 临床应用 药品不良反应/事件 

分 类 号：R979.21[医药卫生—药品]