遗传因素和环境因素在自闭症中的作用  

Genetic and environmental risk factors in autism

作　　者：曹涛[1] 余丹[1] 黄伏生[1] 

机构地区：[1]武汉大学中南医院基因诊断中心,430071

出　　处：《中华临床医师杂志（电子版）》2015年第21期93-97,共5页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金(81171669)

摘　　要：自闭症自1943年首次被认识并命名以来,其病因学研究的发展经历了从最初的生物学到心理学然后再到现在的遗传学、表观遗传学。对该病病因的认识在不断深入,目前认为自闭症是一种复杂的神经疾病,遗传因素、环境因素均与自闭症的发生有关。这篇综述将从这两个方面归纳近些年来自闭症的病因学研究进展。Since autism was first recognized and denominated in 1943, speculation about its etiology has ranged from biological to psychological and to the recently genetic and epigenetic. Insights have been deepened meanwhile, today, it is well acknowledged that autism is a complicated neurodevelopmental disorder with genetic and environmental factors implicated in it. The present review was aimed to summarize key findings from the two perspectives.

关 键 词：自闭症 生物信号通路 危险因素 

分 类 号：R749.94[医药卫生—神经病学与精神病学]