镍铬合金修复体对患者牙龈组织致敏性的研究  

Experimental Study of Hyper-Sensitization in Gingival Tissue After Dental Ni-Cr Alloy Prosthetic Restoration

作　　者：陈爱和[1] 邓秋明[2] 李惠山[1] 

机构地区：[1]大连市友谊医院口腔科,辽宁大连116001 [2]大连医科大学附属第一医院重症医学科,辽宁大连116011

出　　处：《黑龙江医药》2015年第5期1045-1046,共2页Heilongjiang Medicine journal

摘　　要：目的：探讨镍铬合金修复体对患者牙龈组织的致敏性。方法：选择行镍铬合金冠/桥修复固定义齿2～5年的患者30例,取镍铬复体患者牙龈组织及正常对照牙龈组织,运修用免疫组织化学SP（Streptavidin-peroxidase）法检测镍铬修复体患者牙龈组织以及正常牙龈组织中HLA-DR蛋白的表达。结果：镍铬修复体患者牙龈组织中HLA-DR蛋白的表达明显高于正常牙龈组织（P〈0.05）,HLA-DR的阳性表达与患者性别、年龄及修复体类型均无直接关系（P〉0.05）。结论：镍铬合金可能对牙龈组织有一定的致过敏性,可使修复体周围组织处于炎症激活状态。Objective：To investigate hypersensitization in gingival tissue after dental Ni-Cr alloy prosthetic restoration.Methods：Patients who accepted half Ni-Cr alloy crowns or fixed bridges were selected.Immunohistochemical streptavidin peroxidase method was used to detect the expression of HLA-DR in the gingiva samples affected for Ni-Cr alloys two or five year later and normal gingiva tissue samples.Results：Compared to normal gingiva tissue,the HLA-DR positive rate in the gingiva samples affected for Ni-Cr alloys was significantly increased（P〈0.05）.But HLA-DR positive expression had no direct relationship with patients＇ gender,age,prosthetic category（P〉0.05）.Conclusion：Ni-Cr alloys maybe have hyper-sensitization to the gingiva tissue being in activated inflammatory state.

关 键 词：镍铬合金 HLA-DR 致敏性 

分 类 号：R783[医药卫生—口腔医学]