Synthesis and Acid-Catalyzed Cyclization of 2-Alkenylstilbenes： a New Approach to the Substituted Indenes  

作　　者：Wei Ding Xiaoxin Shi Xia Lu 

机构地区：[1]Department of Pharmaceutical Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

出　　处：《Chinese Journal of Chemistry》2015年第11期1276-1286,共11页中国化学（英文版）

基　　金：We are grateful to the National Natural Science Foundation of China （No. 20972048） for the financial support of this work

摘　　要：A base-catalyzed ring-opening of 1-benzylisochromans 1 firstly produced 2-alkenylstilbenes 2, which then underwent a mild acid-catalyzed intramolecular cyclization to furnish 1,2-disubstituted indenes 3 in high yields. Subsequently, a base-catalyzed isomerization of the 1,2-disubstituted indenes 3 afforded the more stable 2,3-disubstituted indenes 4 in almost quantitative yields.A base-catalyzed ring-opening of 1-benzylisochromans 1 firstly produced 2-alkenylstilbenes 2, which then underwent a mild acid-catalyzed intramolecular cyclization to furnish 1,2-disubstituted indenes 3 in high yields. Subsequently, a base-catalyzed isomerization of the 1,2-disubstituted indenes 3 afforded the more stable 2,3-disubstituted indenes 4 in almost quantitative yields.

关 键 词：ISOCHROMAN STILBENE INDENE CYCLIZATION ring-opening synthetic methodology 

分 类 号：O643.36[理学—物理化学] TB333[理学—化学]