c-Met和p-Akt与胃癌血管生成拟态的关系  

Relationship between Expression of c-Met and p-Akt and Vasculogenic Mimicry in Gastric Cancer

作　　者：苏会玲[1] 苏红慧[1] 陈雪霁[1] 蔺强[1] 陈坤[1] 刘风玲[2] 

机构地区：[1]河北医科大学附属华北石油管理局总医院,062552 [2]河北医科大学第四医院,050011

出　　处：《实用癌症杂志》2016年第1期43-46,共4页The Practical Journal of Cancer

摘　　要：目的探讨p-Akt蛋白与HGF/c-Met通路是否参与胃癌VM的形成及其可能的分子机制。方法按照入组标准与排除标准,收集胃癌患者共74例,正常对照患者16例。应用免疫组织化学法,检测肿瘤组织及正常对照组中c-Met受体、p-Akt蛋白的表达情况,应用CD-34和PAS双染法测定VM。结果 c-Met受体与VM表达呈显著正相关(γ=0.277,P<0.05),p-Akt蛋白和VM的表达呈显著正相关(γ=0.409,P<0.05),表明c-Met受体、p-Akt蛋白与胃癌VM的生成存在显著相关性。结论胃癌组织中存在血管生成拟态。c-Met受体、p-Akt蛋白在胃癌VM发生中可能起重要作用。Objective To explore the correlation between p-Akt protein and HGF/c-Met pathway in gastric cancer and their association with vasculogenic mimicry（ VM）. Methods According to the inclusion criteria and the exclusion criteria,a total of 74 cases of gastric cancer patients,and 16 cases of normal control patients were collected. The expression of c-Met receptor and p-Akt protein in the tumor tissues and the normal control group were detected by immunohistochemical method,CD-34 and PAS double staining were used to detect VM. Results The expression of c-Met receptor and VM was significantly positively correlated（ γ = 0. 277,P〈0. 05）,the p-Akt protein and VM was significantly positively correlated（ γ = 0. 409,P〈0. 05）,indicated that the expression of c-Met receptor and p-Akt protein were significantly positively correlated with VM. Conclusion VM exists in gastric carcinoma. C-Met receptor and p-Akt protein may play important role in the occurrence of VM in gastric cancer.

关 键 词：胃癌 C-MET P-AKT VM 血管生成 通路 

分 类 号：R735.2[医药卫生—肿瘤]