172例新疆哈萨克族食管鳞状细胞癌临床病理资料分析  

The clinicopathological data of 172 patient with esophageal squamous cell carcinoma in the Kazak population in Xinjiang

作　　者：王慧[1] 李梦妍 袁媛[3] 叶菁[3] 马遇庆[1] 

机构地区：[1]新疆医科大学第一附属医院病理科,新疆乌鲁木齐830054 [2]新疆油田公司准东采油厂职工医院病理室,新疆阜康831511 [3]第四军医大学病理学教研室,陕西西安710032

出　　处：《现代肿瘤医学》2016年第4期562-565,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81260308)

摘　　要：目的:探讨新疆哈萨克族食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)流行病学特征,并结合临床资料及免疫表型分析。方法:收集了172例新疆哈萨克族ESCC患者资料,分析其临床病理资料,对标本进行免疫组化染色观察。结果:69.2%新疆哈萨克族ESCC患者<65岁,病变多在食管的中下段。其病理学分期,多以T3+T4为主。哈萨克族ESCC组织Cyclin D1阳性表达显著高于汉族ESCC(P=0.025)。结论:新疆哈萨克族ESCC具有种族特异性,推测Cyclin D1是哈萨克族食管癌的主要致病基因。Objective： To understand the epidemiological characteristics of esophageal squamous cell carcinoma（ ESCC） in the Kazak population in Xinjiang by invetigating the clinical and immunophenotypic features. Methods：The data of 172 cases of Xinjiang Hazak patients with esophageal squamous cell carcinoma were collected. The histopathological and immunohistochemical studies were performed. Results： 69. 2 percent of Xinjiang Hazak patients with esophageal squamous cell carcinoma was under 65 years of age. Its pathological stage were mostly seen in T3＋ T4 stage. In Kazak＇s esophageal squamous cell carcinoma,the expression of Cyclin D1 was significantly higher than that of Han＇s patients（ P = 0. 025）. Conclusion： Xinjiang Hazak＇s esophageal squamous cell carcinoma possesracial specificity. So speculated that Cyclin D1 was a major cause in Hazak＇s esophageal cancer.

关 键 词：食管鳞状细胞癌 哈萨克族 KI-67 p53 CYCLIN D1 

分 类 号：R735.1[医药卫生—肿瘤]