几种镍剂对小鼠致癌作用的实验研究  

STUDY ON CARCINOGENIC ACTIVITY OF SEVERAL NICKEL COMPOUNDS IN MICE

作　　者：王朝俊[1] 江映红[1] 李玉琼[1] 邓士林 罗德元[1] 肖恒怡[1] 

机构地区：[1]华西医大肿瘤研究所

出　　处：《华西医科大学学报》1989年第3期307-310,共4页Journal of West China University of Medical Sciences

摘　　要：应用某镍冶炼厂作业环境中存在的几种镍剂,给三种小鼠右腋皮下注射,每鼠5mg,观察62周。仅见镍精砂(主要含Ni_3S_2)有局部诱癌作用。其病理组织学表现以纤维肉瘤为主,亦见2例横纹肌肉瘤,大多数肿瘤分化差,有浸润性,个别发生肝、肺转移。此结果提示该厂环境中存在的镍精砂可能对人类也具有致癌危险性,在考虑劳保措施和职业癌的防治中应引起足够重视。This paper reports the result of thetumor in site induced by several nickelcompounds in mice. Three nickel com-pounds (Ni_3S_2, NiCl, pure nickel powder)were injected separately to the right armpitsubcutaneously (5mg/mouse). At the endof the 62nd week, the tested mice weresacrificed.Only nickel sulfide induced tu-mors in the site of injection, the incidenceof tumor was 36%. The majority of thetumors were fibrosarcomas, only 2 rhab-domyosarcomas. The tumors might infil-trate into the surrounding tissues, a fewmetastasized to the liver and/or the lungs.

关 键 词：镍 诱癌 纤维肉瘤 小鼠 浸润 

分 类 号：R730.231[医药卫生—肿瘤]