Relationships among alcoholic liver disease,antioxidants,and antioxidant enzymes  

作　　者：Kyu-Ho Han Naoto Hashimoto Michihiro Fukushima 

机构地区：[1]Department of Food Science,Obihiro University of Agriculture and Veterinary Medicine,Inada,Obihiro,Hokkaido 080-8555,Japan [2]Upland Farming Resource Research Division,NARO Hokkaido Agricultural Research Center,Kasai,Hokkaido 082-0071,Japan

出　　处：《World Journal of Gastroenterology》2016年第1期37-49,共13页世界胃肠病学杂志（英文版）

基　　金：Supported by JSPS KAKENHI Grant Number 25450196;grants-in-aid from The Ministry of Agriculture,Forestry and Fisheries of Japan

摘　　要：Excessive consumption of alcoholic beverages is a serious cause of liver disease worldwide.The metabolism of ethanol generates reactive oxygen species,which play a significant role in the deterio-ration of alcoholic liver disease(ALD).Antioxidant phytochemicals,such as polyphenols,regulate the expression of ALD-associated proteins and peptides,namely,catalase,superoxide dismutase,glutathione,glutathione peroxidase,and glutathione reductase.These plant antioxidants have electrophilic activity and may induce antioxidant enzymes via the Kelch-like ECH-associated protein 1--NF--E2--related factor--2 pathway and antioxidant responsive elements.Furthermore,these antioxidants are reported to alleviate cell injury caused by oxidants or inflammatory cytokines.These phenomena are likely induced via the regulation of mitogen--activating protein kinase(MAPK)pathways by plant antioxidants,similar to preconditioning in ischemia-reperfusion models.Although the relationship between plant antioxidants and ALD has not been adequately investigated,plant antioxidants may be preventive for ALD because of their electrophilic and regulatory activities in the MAPK pathway.Excessive consumption of alcoholic beverages is a serious cause of liver disease worldwide.The metabolism of ethanol generates reactive oxygen species,which play a significant role in the deterio-ration of alcoholic liver disease(ALD).Antioxidant phytochemicals,such as polyphenols,regulate the expression of ALD-associated proteins and peptides,namely,catalase,superoxide dismutase,glutathione,glutathione peroxidase,and glutathione reductase.These plant antioxidants have electrophilic activity and may induce antioxidant enzymes via the Kelch-like ECH-associated protein 1--NF--E2--related factor--2 pathway and antioxidant responsive elements.Furthermore,these antioxidants are reported to alleviate cell injury caused by oxidants or inflammatory cytokines.These phenomena are likely induced via the regulation of mitogen--activating protein kinase(MAPK)pathways by plant antioxidants,similar to preconditioning in ischemia-reperfusion models.Although the relationship between plant antioxidants and ALD has not been adequately investigated,plant antioxidants may be preventive for ALD because of their electrophilic and regulatory activities in the MAPK pathway.

关 键 词：ELECTROPHILE Mitogen-activating PROTEINKINASE Plant ANTIOXIDANTS reactive oxygen species PRECONDITIONING 

分 类 号：R575[医药卫生—消化系统]