PROTEINKINASE

作品数：12被引量：109H指数：7
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相关领域：医药卫生更多>>
相关作者：曾莉钱海华周邦华赖先荣范刚更多>>
相关机构：江苏省中医院成都中医药大学首都医科大学西安交通大学更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金广东省自然科学基金中国博士后科学基金更多>>
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Banxia Xiexin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice
《Chinese Journal of Integrative Medicine》2024年第8期701-712,共12页GAO Chen-yan QIN Gao-feng ZHENG Ming-cui TIAN Mei-jing HE Yan-nan WANG Peng-wen 
Supported by the Special Fund for Basic Scientific Research Operating Fees of Central Universities(No.2019-BUCMXJKY018)。
Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 mice.Methods Forty-five 3-month-old male APP/PS1 mice were divid...
关键词：Banxia Xiexin Decoction Alzheimer's disease intestinal microbiota glucagon-like peptide 1 cerebral insulin resistance phosphoinositide-3-kinase/proteinkinase B/glycogen synthase kinase-3β Chinese medicine 
通便汤对STC大鼠模型结肠组织中PKA/MPKA信号通路的影响被引量：18
《中国实验方剂学杂志》2019年第5期135-142,共8页万叶敏 曾莉 钱海华 
国家自然科学基金面上项目(81573979)
目的:探讨通便汤对慢传输型便秘(slow transit constipation,STC)大鼠模型结肠组织中蛋白激酶A(protein kinase A,PKA)/丝裂原活化激酶(mitogen-activated protein kinase,MAPK)信号通路的影响及相关机制。方法:80只SD大鼠随机分为正常...
关键词：通便汤 慢传输型便秘 蛋白激酶A(protein kinase A PKA)/丝裂原活化激酶(mitogen-activated proteinkinase MAPK)信号通路 水通道蛋白3 4 
Salvianolate Reduces Murine Myocardial Ischemia and Reperfusion Injury via ERK1/2 Signaling Pathways in vivo被引量：17
《Chinese Journal of Integrative Medicine》2017年第1期40-47,共8页QI Jian-yong YU Juan HUANG Dong-hui GUO Li-heng WANG Lei HUANG Xin HUANG Hai-ding ZHOU Miao ZHANG Min-zhou Jiashin Wu 
Supported by National Natural Science Foundation of China(No.81473471 and No.81573708);Foundation of Guangdong Hospital of Chinese Medicine(No.YK2013B2N11,No.YN2014ZH01,and No.YN2014ZHR203)
Objective： To analyze the effects of salvianolate on myocardial infarction in a murine in vivo model of ischemia and reperfusion （I/R） injury. Metheds： Myocardial I/R injury model was constructed in mice by 30 min...
关键词：ischemia and reperfusion injury SALVIANOLATE extracellular signal-regulated kinase 1/2 proteinkinase B Chinese medicine 
Relationships among alcoholic liver disease,antioxidants,and antioxidant enzymes被引量：17
《World Journal of Gastroenterology》2016年第1期37-49,共13页Kyu-Ho Han Naoto Hashimoto Michihiro Fukushima 
Supported by JSPS KAKENHI Grant Number 25450196;grants-in-aid from The Ministry of Agriculture,Forestry and Fisheries of Japan
Excessive consumption of alcoholic beverages is a serious cause of liver disease worldwide.The metabolism of ethanol generates reactive oxygen species,which play a significant role in the deterio-ration of alcoholic l...
关键词：ELECTROPHILE Mitogen-activating PROTEINKINASE Plant ANTIOXIDANTS reactive oxygen species PRECONDITIONING 
Metabolic derivatives of alcohol and the molecular culpritsof fibro-hepatocarcinogenesis:Allies or enemies?被引量：4
《World Journal of Gastroenterology》2016年第1期50-71,共22页Alex Boye Yu-Hong Zou Yan Yang 
Supported by National Natural Science Foundation of China,No.81374012 and No.81573652
Chronic intake of alcohol undoubtedly overwhelms the structural and functional capacity of the liver by initiating complex pathological events characterized by steatosis,steatohepatitis,hepatic fibrosis and cirrhosis....
关键词：Alcoholic hepatitis Lipopolysaccharide Fibro-hepatocarcinogenesis Mitogen activated PROTEINKINASE Transforming growth factor beta Small motheragainst DECAPENTAPLEGIC 
Regulation of extracellular signal-regulated kinase 1/2 influences hippocampal neuronal survival in a rat model of diabetic cerebral ischemia被引量：10
《Neural Regeneration Research》2014年第7期749-756,共8页Yaning Zhao Jianmin Li Qiqun Tang Pan Zhang Liwei Jing Changxiang Chen Shuxing Li 
supported by the Hebei Province Natural Science Program,No.H2012401007;a grant from the foundation Key Project of Hebei Province Education Ministry,No.ZD2010106
Activation of extracellular signal-regulated kinase 1/2 has been demonstrated in acute brain ischemia. We hypothesized that activated extracellular signal-regulated kinase 1/2 can protect hippocampal neurons from inju...
关键词：nerve regeneration brain injury cerebral ischemia/reperfusion DNA dependent proteinkinase extracellular signal-regulated kinase Bax apoptosis HIPPOCAMPUS neural regeneration 
The role of AMP-activated protein kinase in quercetin-induced apoptosis of HL-60 cells被引量：2
《Acta Biochimica et Biophysica Sinica》2014年第5期394-400,共7页Jie Xiao Guomin Niu Songmei Yin Shuangfeng Xie Yiqing Li Danian Nie Liping Ma Xiuju Wang Yudan Wu 
This work was supported by the grant from the Natural Science Foundation of Guangdong Province （No. 9151008901000105）.
Our previous studies have shown that quercetin inhibits Cox-2 and Bcl-2 expressions, and induces human leukemia HL-60 cell apoptosis. In order to investigate the role of AMP-activated protein kinase （AMPK） on querce...
关键词：LEUKEMIA QUERCETIN AMP-activated proteinkinase CYCLOOXYGENASE-2 
Metformin attenuates pressure overload-induceced cardiac hypertrophy via AMPK activation被引量：16
《Acta Pharmacologica Sinica》2011年第7期879-887,共9页Yong-nan FU Han XIAO Xiao-wei MA Sheng-yang JIANG MingXU You-yi ZHANG 
Aim： To identify the role of metformin in cardiac hypertrophy and investigate the possible mechanism underlying this effect. Methods： Wild type and AMPKα2 knockout （AMPKα2-/-） littermates were subjected to left ...
关键词：METFORMIN cardiac hypertrophy AMP-activated protein kinase protein synthesis transverse aortic constriction Akt/proteinkinase B mammalian target of rapamycin 
Hyperhomocysteinemia stimulates hepatic glucose output and PEPCK expression被引量：14
《Acta Biochimica et Biophysica Sinica》2009年第12期1027-1032,共6页Xue Yu Youguang Huang Qiang Hu Lanqing Ma 
Homocysteine is an intermediate in the sulfur amino acid metabolism. Recent studies suggested that there might be links between hyperhomocysteinemia and insulin resistance. In the present study, we investigated the ef...
关键词：HOMOCYSTEINE insulin resistance phosphoenolpymvate carboxykinase （PEPCK） proteinkinase A 
Dendroaspis natriuretic peptide relaxes gastric antral circular smooth muscle of guinea-pig through thecGMP/cGMP-dependent protein kinase pathway被引量：1
《World Journal of Gastroenterology》2008年第35期5461-5466,共6页Chun-Yu Cai Zheng-Xu Cai Xin-Yi Gu Lu-Juan Shan Yong-Xiao Wang Xue-Zhe Yin Qing-Hui Qi Hui-Shu Guo 
The National Natural Science Foundation of China, No. 30800382;the Youth Science Foundation of Dalian to Professor Hui-Shu Guo, No. 2006B3NS218
AIM: To systematically investigate if cGMP/cGMP- dependent protein kinase G (PKG) signaling pathway may participate in dendroaspis natriuretic peptide (DNP)-induced relaxation of gastric circular smooth muscle. METHOD...
关键词：Dendroaspis natriuretic peptide Cyclic guanosine monophosphate Protein kinase G Proteinkinase A Gastric motility 
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