Targeting adeno-associated virus and adenoviral genetherapy for hepatocellular carcinoma  

作　　者：Yi-Gang Wang Pan-Pan Huang Rong Zhang Bu-Yun Ma Xiu-Mei Zhou Yan-Fang Sun 

机构地区：[1]Xinyuan Institute of Medicine and Biotechnology,School of Life Sciences,Zhejiang Sci-Tech University,Hangzhou 310018,Zhejiang Province,China

出　　处：《World Journal of Gastroenterology》2016年第1期326-337,共12页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China.No.81272687;Zhejiang Provincial Public Welfare Technology Application Research Projects,No.2014C33275;Zhejiang Provincial Natural Science Foundation of China,No.LZ13H160004;the Grant for 521 Talent Project of Zhejiang Sci-Tech University,Hangzhou,China

摘　　要：Human hepatocellular carcinoma(HCC)heavily endangers human heath worldwide.HCC is one of most frequent cancers in China because patients with liver disease,such as chronic hepatitis,have the highest cancer susceptibility.Traditional therapeutic approaches have limited efficacy in advanced liver cancer,and novel strategies are urgently needed to improve the limited treatment options for HCC.This review summarizes the basic knowledge,current advances,and future challenges and prospects of adeno-associated virus(AAV)and adenoviruses as vectors for gene therapy of HCC.This paper also reviews the clinical trials of gene therapy using adenovirus vectors,immunotherapy,toxicity and immunological barriers for AAV and adenoviruses,and proposes several alternative strategies to overcome the therapeutic barriers to using AAV and adenoviruses as vectors.Human hepatocellular carcinoma(HCC)heavily endangers human heath worldwide.HCC is one of most frequent cancers in China because patients with liver disease,such as chronic hepatitis,have the highest cancer susceptibility.Traditional therapeutic approaches have limited efficacy in advanced liver cancer,and novel strategies are urgently needed to improve the limited treatment options for HCC.This review summarizes the basic knowledge,current advances,and future challenges and prospects of adeno-associated virus(AAV)and adenoviruses as vectors for gene therapy of HCC.This paper also reviews the clinical trials of gene therapy using adenovirus vectors,immunotherapy,toxicity and immunological barriers for AAV and adenoviruses,and proposes several alternative strategies to overcome the therapeutic barriers to using AAV and adenoviruses as vectors.

关 键 词：Hepatocellular carcinoma Adeno-associatedvirus ADENOVIRUS VIRUS VECTORS 

分 类 号：R735.7[医药卫生—肿瘤]