Recent advances in photodynamic diagnosis of gastriccancer using 5-aminolevulinic acid  

作　　者：Noriaki Koizumi Yoshinori Harada Takeo Minamikawa Hideo Tanaka Eigo Otsuji Tetsuro Takamatsu 

机构地区：[1]Department of Pathology and Cell Regulation,Graduate School of Medical Science,Kyoto Prefectural University of Medicine,Kyoto 6028566,Japan [2]Division of Digestive Surgery,Department of Surgery,Graduate School of Medical Science,Kyoto Prefectural University of Medicine,Kyoto 6028566,Japan [3]Department of Surgery,Nishijin Hospital,Kyoto 6028319,Japan [4]Department of Medical Photonics,Graduate School of Medical Science,Kyoto Prefectural University of Medicine,Kyoto 6028566,Japan

出　　处：《World Journal of Gastroenterology》2016年第3期1289-1296,共8页世界胃肠病学杂志（英文版）

摘　　要：Photodynamic diagnosis based on 5-aminolevulinic acidinduced protoporphyrin IX has been clinically applied in many fields based upon its evidenced efficacy and adequate safety. In order to establish a personalized medicine approach for treating gastric cancer patients, rapid intraoperative detection of malignant lesions has become important. Feasibility of photodynamic diagnosis using 5-aminolevulinic acid for gastric cancer patients has been investigated, especially for the detection of peritoneal dissemination and lymph node metastasis. This method enables intraoperative realtime fluorescence detection of peritoneal dissemination, exhibiting higher sensitivity than white light observation without histopathological examination. The method also enables detection of metastatic foci within excised lymph nodes, exhibiting a diagnostic accuracy comparable to that of a current molecular diagnostics technique. Although several complicating issues still need to be resolved, such as the effect of tissue autofluorescence and the insufficient depth penetration of excitation light, this simple and rapid method has the potential to become a useful diagnostic tool for gastric cancer, as well as urinary bladder cancer and glioma.Photodynamic diagnosis based on 5-aminolevulinic acidinduced protoporphyrin IX has been clinically applied in many fields based upon its evidenced efficacy and adequate safety. In order to establish a personalized medicine approach for treating gastric cancer patients, rapid intraoperative detection of malignant lesions has become important. Feasibility of photodynamic diagnosis using 5-aminolevulinic acid for gastric cancer patients has been investigated, especially for the detection of peritoneal dissemination and lymph node metastasis. This method enables intraoperative realtime fluorescence detection of peritoneal dissemination, exhibiting higher sensitivity than white light observation without histopathological examination. The method also enables detection of metastatic foci within excised lymph nodes, exhibiting a diagnostic accuracy comparable to that of a current molecular diagnostics technique. Although several complicating issues still need to be resolved, such as the effect of tissue autofluorescence and the insufficient depth penetration of excitation light, this simple and rapid method has the potential to become a useful diagnostic tool for gastric cancer, as well as urinary bladder cancer and glioma.

关 键 词：Gastric cancer Photodynamic diagnosis 5-aminolevulinic acid PROTOPORPHYRIN IX LYMPH nodemetastasis PERSONALIZED medicine PERITONEAL DISSEMINATION 

分 类 号：R735.2[医药卫生—肿瘤]