Glucose metabolism in gastric cancer:The cutting-edge  

作　　者：Lian-Wen Yuan Hiroharu Yamashita Yasuyuki Seto 

机构地区：[1]Department of Geriatric Surgery,Second Xiangya Hospital,Center-South University,Changsha 410011,Hunan Province,China [2]Department of Gastrointestinal Surgery,Graduate School of Medicine,University of Tokyo,Tokyo 113-8655,Japan

出　　处：《World Journal of Gastroenterology》2016年第6期2046-2059,共14页世界胃肠病学杂志（英文版）

基　　金：Supported by The China Scholarship Council;No.[2014]3012

摘　　要：Glucose metabolism in gastric cancer cells differs from that of normal epithelial cells. Upregulated aerobic glycolysis(Warburg effect) in gastric cancer meeting the demands of cell proliferation is associated with genetic mutations, epigenetic modification and proteomic alteration. Understanding the mechanisms of aerobic glycolysis may contribute to our knowledge of gastric carcinogenesis. Metabolomic studies offer novel, convenient and practical tools in the search for new biomarkers for early detection, diagnosis, prognosis, and chemosensitivity prediction of gastric cancer. Interfering with the process of glycolysis in cancer cells may provide a new and promising therapeutic strategy for gastric cancer. In this article, we present a brief review of recent studies of glucose metabolism in gastric cancer, with primary focus on the clinical applications of new biomarkers and their potential therapeutic role in gastric cancer.Glucose metabolism in gastric cancer cells differs from that of normal epithelial cells. Upregulated aerobic glycolysis(Warburg effect) in gastric cancer meeting the demands of cell proliferation is associated with genetic mutations, epigenetic modification and proteomic alteration. Understanding the mechanisms of aerobic glycolysis may contribute to our knowledge of gastric carcinogenesis. Metabolomic studies offer novel, convenient and practical tools in the search for new biomarkers for early detection, diagnosis, prognosis, and chemosensitivity prediction of gastric cancer. Interfering with the process of glycolysis in cancer cells may provide a new and promising therapeutic strategy for gastric cancer. In this article, we present a brief review of recent studies of glucose metabolism in gastric cancer, with primary focus on the clinical applications of new biomarkers and their potential therapeutic role in gastric cancer.

关 键 词：GLUCOSE METABOLISM WARBURG effect Metabolomics GASTRIC cancer BIOMARKER Therapy 

分 类 号：R735.2[医药卫生—肿瘤]