Hypoalbuminemia in colorectal cancer prognosis:Nutritional marker or inflammatory surrogate?  

作　　者：Bassel Nazha Elias Moussaly Mazen Zaarour Chanudi Weerasinghe Basem Azab 

机构地区：[1]Department of Medicine,North Shore-LIJ Staten Island University Hospital [2]Department of General Surgery,Arnot Medical Center

出　　处：《World Journal of Gastrointestinal Surgery》2015年第12期370-377,共8页世界胃肠外科杂志（英文版）（电子版）

摘　　要：Albumin is the single most abundant protein in the human serum. Its roles in physiology and pathology are diverse. Serum albumin levels have been classically thought to reflect the nutritional status of patients. This concept has been challenged in the last two decades as multiple factors, such as inflammation, appeared to affect albumin levels independent of nutrition. In general, cancer patients have a high prevalence of hypoalbuminemia. As such, the role of hypoalbuminemia in patients with colorectal cancer has received significant interest. We reviewed the English literature on the prognostic value of pretreatment albumin levels in colorectal cancer. We also consolidated the evidence that led to the current understanding of hypoalbuminemia as an inflammatory marker rather than as a nutritional one among patients with colorectal cancer.Albumin is the single most abundant protein in the human serum. Its roles in physiology and pathology are diverse. Serum albumin levels have been classically thought to reflect the nutritional status of patients. This concept has been challenged in the last two decades as multiple factors, such as inflammation, appeared to affect albumin levels independent of nutrition. In general, cancer patients have a high prevalence of hypoalbuminemia. As such, the role of hypoalbuminemia in patients with colorectal cancer has received significant interest. We reviewed the English literature on the prognostic value of pretreatment albumin levels in colorectal cancer. We also consolidated the evidence that led to the current understanding of hypoalbuminemia as an inflammatory marker rather than as a nutritional one among patients with colorectal cancer.

关 键 词：HYPOALBUMINEMIA ALBUMIN COLORECTALCANCER Albumin-to-globulin ratio Cancer survival Systemic INFLAMMATORY response GLASGOW prognosticscore 

分 类 号：R735.34[医药卫生—肿瘤]