Isoflavones and Prostate Cancer： A Review of Some Critical Issues  

作　　者：Hong-Yi Zhang Jie Cui Ye Zhang Zhen-Long Wang Tie Chong Zi-Ming Wang 

机构地区：[1]Department of Urology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China [2]Department of Urology, Yan'an University Affiliated Hospital, Yan'an, Shaanxi 716000, China [3]Department of Oncology, Yan'an University Affiliated Hospital, Yan'an, Shaanxi 716000, China

出　　处：《Chinese Medical Journal》2016年第3期341-347,共7页中华医学杂志（英文版）

摘　　要：Objective： The purpose of this review is to discuss some critical issues of isoflavones protective against the development of prostate cancer （PCa）.Data Sources： Data cited in this review were obtained primarily from PubMed and Embase from 1975 to 2015.Study Selection： Articles were selected with the search terms ＆quot;isoflavone＆quot;, ＆quot;Phytoestrogen＆quot;, ＆quot;soy＆quot;, ＆quot;genistin＆quot;, and ＆quot;PCa＆quot;.Results： Isoflavones do not play an important role on prostate-specific antigen levels reduction in PCa patients or healthy men.The effect ofisoflavones on sex hormone levels and PCa risk may be determined by equol converting bacteria in the intestine, specific polymorphic variation and concentrations of isoflavones.The intake of various types of phytoestrogens with lower concentrations in the daily diet may produce synergistic effects against PCa.Moreover, prostate tissue may concentrate isoflavones to potentially anti-carcinogenic levels.In addition, it is noteworthy that isoflavones may act as an agonist in PCa.Conclusions： Isoflavones play a protective role against the development of PCa.However, careful consideration should be given when isoflavones are used in the prevention and treatment of PCa.Objective： The purpose of this review is to discuss some critical issues of isoflavones protective against the development of prostate cancer （PCa）.Data Sources： Data cited in this review were obtained primarily from PubMed and Embase from 1975 to 2015.Study Selection： Articles were selected with the search terms ＆quot;isoflavone＆quot;, ＆quot;Phytoestrogen＆quot;, ＆quot;soy＆quot;, ＆quot;genistin＆quot;, and ＆quot;PCa＆quot;.Results： Isoflavones do not play an important role on prostate-specific antigen levels reduction in PCa patients or healthy men.The effect ofisoflavones on sex hormone levels and PCa risk may be determined by equol converting bacteria in the intestine, specific polymorphic variation and concentrations of isoflavones.The intake of various types of phytoestrogens with lower concentrations in the daily diet may produce synergistic effects against PCa.Moreover, prostate tissue may concentrate isoflavones to potentially anti-carcinogenic levels.In addition, it is noteworthy that isoflavones may act as an agonist in PCa.Conclusions： Isoflavones play a protective role against the development of PCa.However, careful consideration should be given when isoflavones are used in the prevention and treatment of PCa.

关 键 词：ISOFLAVONE PHYTOESTROGEN Prostate Cancer 

分 类 号：Q78[生物学—分子生物学] TS214.2[轻工技术与工程—粮食、油脂及植物蛋白工程]