肿瘤代谢与肿瘤转移  

Cancer metabolism and metastasis

作　　者：王祥宇[1,2] 郑燕[1,2,3] 鲁明[1,2] 钦伦秀[1,2,3] 

机构地区：[1]复旦大学附属华山医院普外科,上海200040 [2]复旦大学肿瘤转移研究所,上海200040 [3]复旦大学生物医学研究院,上海200032

出　　处：《复旦学报（医学版）》2016年第1期86-93,共8页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金国际(地区)合作与交流项目(8112108016)~~

摘　　要：在肿瘤的发生、发展过程中,肿瘤细胞的代谢会改变为特定的谱式以适应肿瘤的快速生长。近年来的研究表明,肿瘤的代谢与肿瘤的转移也存在密切联系。本文主要从肿瘤细胞代谢及肿瘤微环境中的代谢两方面综述肿瘤代谢在肿瘤转移中的作用及机制的研究进展。Metastasis and metabolic deregulation are two of the major essential hallmarks of cancer.In the initiation and development of cancer,tumor cells are known to undergo metabolic alterations to sustain faster proliferation.Recent studies indicated that metabolic changes of tumors are also closely related to tumor metastasis.In this review,we summarize the research progress about the roles and related mechanism of tumor metabolism in tumor metastasis from the aspects of both the tumor cell and microenvironment.

关 键 词：糖类 氨基酸 胆固醇 脂肪酸 肿瘤微环境 肿瘤转移 

分 类 号：R730[医药卫生—肿瘤]