Effect of compound Kushen injection on T-cell subgroups and natural killer cells in patients with locally advanced non-small-cell lung cancer treated with concomitant radiochemotherapy  

作　　者：Zhao Zhongquan Liao Hehe Ju Ying 

机构地区：[1]Department of Oncology, Fuzhou General Hospital of Nanjing Military Region [2]Department of Tumor Surgery, Affiliated Hospital of Xi'an Medical College [3]Department of Obstetrics and Gynecology, Tangdu Hospital, the Fourth Military Medical University

出　　处：《Journal of Traditional Chinese Medicine》2016年第1期14-18,共5页中医杂志（英文版）

摘　　要：OBJECTIVE: To observe effect of compound Kushen injection on T-cell subgroups and NK cells in patients with locally advanced non-small-cell lung cancer(NSCLC) treated with concomitant radiochemotherapy.METHODS: We randomly divided 60 patients with locally advanced NSCLC who were treated at our hospital between May 2011 and May 2013 into a treatment group and a control group by drawing.The treatment group(n = 30) received concomitant radiochemotherapy plus compound Keshen injection, and the control group(n = 30) received only radiochemotherapy.RESULTS: After treatment, levels of CD3+, CD4+,CD4 +/CD8 + and CD16 +/CD56 + cells had significantly increased, and CD8 + cells had significantly decreased, in the treatment group compared with both their pretreatment levels and with levels in the control group. In the control group, post-treatment levels of CD3 +, CD4 +, CD4 +/CD8 + and CD16+/CD56+ cells were not significantly changed from pretreatment levels. The two groups did not significantly differ in their rates of toxicity reactions(P > 0.05).CONCLUSION: Compound Kushen injections can increase immunologic function in patients with locally advanced non-small cell lung cancer who receive concomitant radiochemotherapy.OBJECTIVE： To observe effect of compound Kushen injection on T-cell subgroups and NK cells in pa- tients with locally advanced non-small-cell lung cancer （NSCLC） treated with concomitant radioche- motherapy. METHODS： We randomly divided 60 patients with locally advanced NSCLC who were treated at our hospital between May 2011 and May 2013 into a treatment group and a control group by drawing. The treatment group （n = 30） received concomitant radiochemotherapy plus compound Keshen injection, and the control group （n = 30） received only radiochemotherapy. RESULTS： After treatment, levels of CD3＋, CD4＋, CD4 ＋/CD8 ＋ and CD16 ＋/CD56 ＋ cells had significantly increased, and CD8 ＋ cells had significantly decreased, in the treatment group compared with both their pretreatment levels and with levels in the control group. In the control group, post-treatment levels of CD3 ＋, CD4 ＋, CD4 ＋/CD8 ＋ and CD16＋/CD56＋ cells were not significantly changed from pretreatment levels. The two groups did not significantly differ in their rates of toxicity reactions （P 〉 0.05）. CONCLUSION： Compound Kushen injections can increase immunologic function in patients with locally advanced non-small cell lung cancer who receive concomitant radiochemotherapy.

关 键 词：Compound Kushen injection Carcinoma  non-small-cell lung T-LYMPHOCYTES Killer cells natural CHEMORADIOTHERAPY 

分 类 号：R734.2[医药卫生—肿瘤]