Survivin、VEGF、EGFR在甲状腺乳头状癌中的表达及意义  

Expression and significance of Survivin,VEGF and EGFR in papillary thyroid carcinoma

作　　者：汪巧[1,2] 胡向阳[1,2] 张晓亮[3] 丁婧 

机构地区：[1]安徽医科大学病理学教研室,合肥230032 [2]安徽医科大学第一附属医院病理科,合肥230022 [3]安徽省立医院病理科,合肥230001 [4]安徽省胸科医院,合肥230020

出　　处：《安徽医科大学学报》2016年第3期442-446,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家临床重点专科建设项目经费资助(编号:3101005004021)

摘　　要：目的 探讨存活素（Survivin）、血管内皮生长因子（VEGF）、表皮生长因子受体（EGFR）蛋白在甲状腺乳头状癌（PTC）中的意义。方法 采用免疫组化Envision法检测100例PTC以及癌旁正常甲状腺组织中的Survivin、VEGF、EGFR蛋白表达状况。结果 1 Survivin、VEGF和EGFR在PTC中的阳性表达率分别为58%、75%、84%,显著高于癌旁正常甲状腺组织,差异有统计学意义（P〈0.05）;2 Survivin和VEGF在伴有淋巴结转移的乳头状癌组织阳性表达率分别为73.3%、90%,显著高于无转移组,与其它临床病理参数无相关性;3 EGFR在女性患者组织表达率为90.2%,显著高于男性患者55.6%,差异有统计学意义（P〈0.05）;4Survivin与EGFR在PTC中表达存在正相关性（χ2=5.595,P〈0.05,r=0.237）。结论 Survivin、VEGF和EGFR可能参与了甲状腺乳头状癌的发生发展过程,其中Survivin和VEGF可能与肿瘤淋巴结转移有关;Survivin和EGFR可能存在协同作用。VEGF、EGFR在PTC组织中高表达,为将针对VEGF、EGFR靶点的靶向药物用于甲状腺乳头状癌治疗的构想提供了初步的实验依据。Objective To explore the significance of Survivin protein, EGFR protein and VEGF protein in papillary thyroid carcinoma（PTC）. Methods Immunohistochemical staining was performed in 100 specimens of PTC and 100 specimens of adjacent normal thyroid tissue to examine the expression of Survivin protein, VEGF protein and EGFR protein. Results （1） The positive ratios of Survivin, EGFR and VEGF in PTC were 58%, 75% and 84%, which were significantly higher than the expression levels of adjacent normal thyroid tissue. There was all statistical difference between them（ P 〈 0. 05 ）. （3） The positive ratios of Survivin and VEGF in PTC with lymph node metastasis were 73.3% and 90% , which were prominently higher than those without lymph node metastasis. No relationships were found between expression of the makers and other clinicopathological features in PTC. （3） The positive expression rates of EGFR in female patients was 90.2%, dramaticlly higher than that of male patients 55.6%. There was statistical difference between them（ P 〈 0. 05 ）. （4） The expressions of Survivin and VEGF were positively correlated in PTC （ X2 = 5.595, P 〈 0. 05, r = 0. 237 ）. Conclusion The Survivin , VEGF and EGFR may be involved in the occurrence and development process of PTC, Moreover, Survivin and VEGF may promote the procedure of cancer cell spreading to lymph nodes ; there may exist synergistic effect between Survivin and EGFR. The over expression of Survivin, VEGF and EGFR in PTC may provide preliminary experimental basis for the treatment of PTC, which using corresfncollege targeted drugs.

关 键 词：甲状腺乳头状癌 SURVIVIN VEGF EGFR 

分 类 号：R736.1[医药卫生—肿瘤]