Urinary Biomarkers of Brain Diseases  

作　　者：Manxia An Youhe Gao 

机构地区：[1]Department of Pathophysiology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences [2]School of Basic Medicine, Peking Union Medical College [3]Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory of Gene Engineering and Biotechnology

出　　处：《Genomics, Proteomics & Bioinformatics》2015年第6期345-354,共10页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Basic Research Program of China (Grant Nos. 2012CB517606 and 2013CB530805);the Key Basic Research Program of China (Grant No. 2013FY114100)

摘　　要：Biomarkers are the measurable changes associated with a physiological or pathophysio- logical process. Unlike blood, urine is not subject to homeostatic mechanisms. Therefore, greater fluctuations could occur in urine than in blood, better reflecting the changes in human body. The roadmap of urine biomarker era was proposed. Although urine analysis has been attempted for clin- ical diagnosis, and urine has been monitored during the progression of many diseases, particularly urinary system diseases, whether urine can reflect brain disease status remains uncertain. As some biomarkers of brain diseases can be detected in the body fluids such as cerebrospinal fluid and blood, there is a possibility that urine also contain biomarkers of brain diseases. This review summarizes the clues of brain diseases reflected in the urine proteome and metabolome.Biomarkers are the measurable changes associated with a physiological or pathophysio- logical process. Unlike blood, urine is not subject to homeostatic mechanisms. Therefore, greater fluctuations could occur in urine than in blood, better reflecting the changes in human body. The roadmap of urine biomarker era was proposed. Although urine analysis has been attempted for clin- ical diagnosis, and urine has been monitored during the progression of many diseases, particularly urinary system diseases, whether urine can reflect brain disease status remains uncertain. As some biomarkers of brain diseases can be detected in the body fluids such as cerebrospinal fluid and blood, there is a possibility that urine also contain biomarkers of brain diseases. This review summarizes the clues of brain diseases reflected in the urine proteome and metabolome.

关 键 词：Brain diseases URINE PROTEOMICS Metabolomics Biomarkers 

分 类 号：R741[医药卫生—神经病学与精神病学]