人胃癌组织Notch1表达及其意义  

Expression and Significance of Notch1 in Human Gastric Cancer

作　　者：鉏莉[1] 蔡陈效[1] 殷新光[1] 邬万新 

机构地区：[1]嘉兴市第一医院消化内科(嘉兴市医学重点学科胃肠病学),314000 [2]嘉兴市第一医院病理科,314000

出　　处：《胃肠病学》2016年第1期30-33,共4页Chinese Journal of Gastroenterology

摘　　要：背景:胃癌是全球第四大常见恶性肿瘤。Notch信号通路在肿瘤发生机制中的作用为近年研究热点,但其在胃癌中的作用机制尚未完全明确。目的:探讨人胃癌组织中Notch1的表达情况及其意义。方法:纳入2011年10月—2014年7月嘉兴市第一医院收治的胃癌患者115例,采用免疫组化法检测癌组织和相应癌旁非癌组织标本中Notch1的表达情况,并分析Notch1表达与胃癌临床病理特征的关系。结果:Notch1在胃癌组织中的阳性表达率显著高于癌旁非癌组织(73.9%对3.5%,P<0.001)。胃癌组织中的Notch1表达与肿瘤脉管浸润、淋巴结转移、TNM分期显著相关(P<0.05)。结论:Notch1作为促癌基因参与了胃癌的发生,并与胃癌浸润、转移有密切联系。Background： Gastric cancer（ GC） is the fourth commonly seen cancer in the world. The role of Notch signaling pathway in the pathogenesis of tumors has become a focus in related studies,however,the underlying mechanism of Notch1 in GC has not yet been fully understood. Aims： To investigate the expression and significance of Notch1 in human GC tissue. Methods： A total of 115 patients with GC admitted at Jiaxing First Hospital from October 2011 to July 2014 were enrolled. Expression of Notch1 in cancerous tissue and para-cancer noncancerous tissue was determined by immunohistochemistry. The correlation between expression of Notch1 and clinicopathological characteristics of GC was analyzed. Results： Expression rate of Notch1 in cancerous tissue was significantly higher than that in para-cancer noncancerous tissue（ 73. 9% vs. 3. 5%,P〈 0. 001）. Notch1 expression in cancerous tissue was significantly correlated with depth of vascular involvement,lymph node metastasis and TNM stage of GC（ P〈 0. 05）. Conclusions： Notch1 as a cancer-promoting gene is involved in the pathogenesis of GC,and has a close association with tumor invasion and metastasis.

关 键 词：胃肿瘤 NOTCH1 免疫组织化学 幽门螺杆菌 

分 类 号：R735.2[医药卫生—肿瘤]