动物源性食品中喹诺酮类残留前处理及分析方法的研究进展  

Research progress in pretreatment technologies and detection methods of quinolones residues in foods

作　　者：张元[1,2] 周伟娥[2] 李绍辉[2] 郑阳[2] 周昱[1] 张峰[2] 冯雪松[1] 

机构地区：[1]中国医科大学药学院,辽宁沈阳110013 [2]中国检验检疫科学研究院食品安全研究所,北京100176

出　　处：《食品工业科技》2016年第5期378-383,共6页Science and Technology of Food Industry

基　　金：国家重大科学仪器设备开发专项项目(2012YQ14000806);国家质检总局科技计划专项(2014Ik084);北京市科技计划课题(Z141100002614020);质检公益性行业科研专项分项目(201410088-02);辽宁省科学技术厅自然科学基金(201202252)

摘　　要：喹诺酮类兽药残留是目前重要的动物源性食品安全问题之一,检测食物基质中痕量兽药残留依赖于有效的前处理方法和精密的分析仪器。本文阐述了喹诺酮类兽药的研究背景和现状,并对国内外食品中喹诺酮类兽药残留的液液萃取(Liquid-Liquid Extraction,LLE)、固相萃取(Solid-Phase Extraction,SPE)、基质辅助固相分散萃取(Matrix Solid-Phase Dispersion,MSPD)、Qu ECHERs(Quick,Easy,Cheap,Effective,Rugged,Safe,Qu ECHERs)、超临界流体萃取(Supercritical Fluid Extraction,SFE)和免疫亲和色谱(Immunoaffinity Chromatography,IAC)等前处理方法及液相色谱质谱法、液相色谱法、毛细管电泳分析方法及免疫分析测定法等检测方法进行了综述,拟为动物源性食品中喹诺酮类药物的残留监控提供理论参考,综述指出SPE和Qu ECHERs为最有前景的前处理方法,而质谱技术的发展和仪器的小型化为检测仪器的发展趋势。Quinolones residue is currently one of important problems in animal-derived food safety.The detection of quinolones in a complex food matrix mainly relies on an effective pretreatment method and precision instruments. This paper summarized the research background and status of quinolones,and reviewed the research progress in China and other countries on pretreatment technologies, such as liquid-liquid extraction, solid-phase extraction, matrix solid-phase dispersion, QuECHERs, supercritical fluid extraction and immunoaffinity chromatography and detection methods, such as high performance liquid chromatography-tandem mass, high performance liquid chromatography,capillary electrophoresis and immunoassay, this review could provide reference of monitoring quinolones residues in food. The review suggests that SPE and QuECHERs are most promising pretreatment methods,and the development of mass-spectrometric technique and the miniaturization of instrument will be a development trend.

关 键 词：动物源性食品 前处理技术 检测 喹诺酮兽药残留 

分 类 号：TS251.1[轻工技术与工程—农产品加工及贮藏工程]