Alpha B-crystallin蛋白Ser^(59)磷酸化在肝细胞肝癌中的意义  

Significance of Phosphorylated Alpha B-Crystallin(Ser^(59))in Hepatocellular Carcinoma Tissues

作　　者：黄晓勇[1] 柯爱武[1] 施国明[1] 周俭[1] 

机构地区：[1]复旦大学附属中山医院肝外科,上海200032

出　　处：《中国临床医学》2015年第6期734-737,共4页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金项目(编号:81272295)

摘　　要：目的:探讨alpha B-crystallin蛋白Ser^(59)磷酸化在肝细胞肝癌(肝癌)组织中的意义。方法:采用免疫组织化学染色法检测403例肝癌组织中磷酸化的alpha B-crystallin(Ser^(59))的表达水平,分析其与肝癌临床病理特征及预后的关系。结果:磷酸化alpha B-crystallin的表达水平与肿瘤直径、肿瘤包膜、大血管侵犯及肿瘤组织分化有关(P<0.05、0.01),而与肝癌患者年龄、性别、乙肝表面抗原、肝硬化等无关(P>0.05)。多因素分析结果显示,磷酸化alpha B-crystallin的表达水平是肝癌的独立预后因素。结论:磷酸化alpha B-crystallin(Ser^(59))的表达水平与肝癌的恶性表型及不良预后相关。Objective ：To investigate the expression of phosphorylated alpha B-crystallin in hepatocellular carcinoma（HCC） tissues and its significance .Methods ： The expression level of phosphorylated alpha B-crystallin in HCC tissues from 403 cases was detected by immunohistochemical staining ,and its correlation with HCC clinicopathologic features and prognosis was analyzed .Results ： The expression level of phosphorylate alpha B-crystallin （Ser 59 ） was correlated with tumor size ,tumor encapsulation ,vascular invasion and tissue differentiation （ P 〈 0 .05 or 0 .01） . However ,it was not correlated with age , gender ,HBsAg ,liver cirrhosis .Multivariate analysis showed that the expression level of phosphorylated alpha B-crystallin （Ser^59 ） was an independent factor for prognosis .Conclusions ： The expression level of phosphorylated alpha B-crystallin （Ser^59 ） is correlated with the malignant phenotype and poor prognosis of HCC .

关 键 词：磷酸化alpha B-CRYSTALLIN 肝细胞肝癌 预后 

分 类 号：R735.7[医药卫生—肿瘤]