Supported by the DST Nano-mission,Govt of India,Grant No DST No.SR/NM/NS-1067/2016;Facilities were provided by the West Bengal University of Animal&Fishery Sciences and CSIR-IICB for conducting this research。
AIM:To evaluate if topical use of αB-crystallin minipeptides supports corneal healing following flap surgery.METHODS:Cultured corneal cells were treated with fluorescent taggedαB-crystallin mini-peptides to assess i...
supported by the National Natural Science Foundation of China(31872724,and 81900837);the Natural Science Foundation of Zhejiang Province(LR21H120001).
Protein misfolding and aggregation are crucial pathogenic factors for cataracts,which are the leading cause of visual impairment worldwide.α-crystallin,as a small molecular chaperone,is involved in preventing protein...
AIM:To evaluate the effect of epigallocatechin gallate(EGCG) in preventing lens opacity and the aggregation of lens αB-crystallin in model rats of diabetes mellitus(DM).METHODS:This experimental study included Wistar...
目的研究miRNA-491(miR-491)对胶质母细胞瘤细胞上皮间质转化和凋亡的调控作用和机制。方法收集新鲜胶质瘤(glioblastoma multiforme,GBM)13例和对应的癌旁组织(nontumorous tissues,NT)13例。体外培养神经胶质细胞(normal human astroc...
AIM: To investigate the effect of broccoli sprouts juice in preventing lens protein aggregation in diabetic rat model.METHODS: Totally 25 male Wistar rats were divided into negative control group, diabetic group witho...
This work was supported by grants from the Natural Science Foundation of China(31430036,91742116,U1801681);National Key Basic Research Program of China(2015CB553500);Key Research Program of Frontier Sciences(QYZDJ-SSW-SMC002);Strategic Priority Research Program of Chinese Academy of Science(XDB32020100);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the Shanghai Municipal Science and Technology Commission(17ZR1435300 to SZZ).
Background:Parkinson’s disease(PD)is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions(Lewy bodies)within some remaining neurons in the substantia nigra.Recently,ast...