Base mediated direct C–H amination for pyrimidines synthesis from amidines and cinnamaldehydes using oxygen as green oxidants  

作　　者：Wei Guo 

机构地区：[1]School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China [2]Key Laboratory of Organo-pharmaceutical Chemistry ofJiangxi Province, Gannan Normal University, Ganzhou 341000, China

出　　处：《Chinese Chemical Letters》2016年第1期47-50,共4页中国化学快报（英文版）

基　　金：the China Postdoctoral Science Foundation Funded Project (No. 2014M562165);Jiangxi Natural Science Foundation (Nos. 20133BCB24011, 20141BBG70070 and 20151BAB203011);the Science Foundation of Jiangxi Provincial Department of Education (No. Gjj4669) for support of this research

摘　　要：A direct metal-free C-H amination reaction of cinnamaldehydes and amidines to realize the synthesis of polysubstituted pyrimidines was developed in the presence of base. This greener synthetic methodology provides a straightforward approach to the synthesis of a variety of pyrimidine derivatives under mild reaction condition using oxygen as sole oxidants.A direct metal-free C-H amination reaction of cinnamaldehydes and amidines to realize the synthesis of polysubstituted pyrimidines was developed in the presence of base. This greener synthetic methodology provides a straightforward approach to the synthesis of a variety of pyrimidine derivatives under mild reaction condition using oxygen as sole oxidants.

关 键 词：C-H amination PYRIMIDINES AMIDINES Cinnamaldehydes OXYGEN 

分 类 号：O626[理学—有机化学]