PYRIMIDINES

作品数：42被引量：42H指数：4
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相关领域：理学医药卫生更多>>
相关作者：周妮妮谢志翔吴安心更多>>
相关机构：兰州大学西北农林科技大学华中师范大学更多>>
相关期刊：《National Science Review》《Chemical Research in Chinese Universities》《有机化学》《Chinese Journal of Structural Chemistry》更多>>
相关基金：国家自然科学基金中国博士后科学基金天津市自然科学基金国家教育部博士点基金更多>>
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NH_(4)SCN-Promoted Formal[3+3]Annulation for the Synthesis of 5-Arylated Pyrazolo[1,5-a]pyrimidines
《有机化学》2024年第9期2832-2840,共9页Li Longlong He Xinyue Zhou Longsheng Qu Hengtong Feng Chengtao Xu Kun 
安徽省自然科学基金(No.2008085MB50);安徽省高校自然科学研究重点(No.KJ2021A0598)资助项目.
A formal[3+3]annulation of 3-aminopyrazoles with cinnamaldehydes or cinnamyl alcohols mediated by NH_(4)SCN has been developed.This protocol provides a practical route to construct 5-arylated pyrazolo[1,5-a]pyrimidine...
关键词：tandem cyclization hypervalent iodine regioselectivity pyrazolo[1 5-a]pyrimidine CINNAMALDEHYDE 
Heterogeneous photocatalytic methanol oxidation coupled with oxygen reduction toward pyrimidines synthesis
《Science Bulletin》2024年第16期2496-2500,共5页Hongru Wu Jie Wang Hongli Sun Haochuan Jing Zhenyuan Teng Wei Ou Zhaofei Zhang Yangsen Xu Bin Liu Chenliang Su 
supported by the National Key Research and Development Program of China(2021YFA1600800);the National Natural Science Foundation of China(21972094,22372102,and22102102);the Educational Commission of Guangdong Province(839-0000013131);Guangdong Basic and Applied Basic Re-search Foundation(2020A1515010982);Shenzhen Science and Technology Program(RCJC20200714114434086 and 20221425);the Research Team Cultivation Program of Shenzhen University(2023QNT013)。
Pyrimidines and their derivatives are widely found in natural products,agrochemicals,and pharmaceutical compounds,such as osimertinib,tofacitinnib,nilotinib,and fluoxastrobin(Fig.S1 online)[1].Considering their signif...
关键词：PYRIMIDINE METHANOL SYNTHESIS 
Switchable Multicomponent Cyclization Reactions to Access Fluoroalkylated Dihydropyrimidines and Pyrimidines under Solvent-Free Conditions
《Chinese Journal of Chemistry》2024年第12期1394-1398,共5页Wanqing Zuo Zhizhen Zhu Yu Cheng Lingling Zuo Xiao Geng Zhifang Li Lei Wang 
the National Natural Science Foundation of China(22071171);the Natural Science Foundation of Zhejiang Province(LZ22B020003)for financial support of this work.
Comprehensive Summary The development of switchable solvent-free multicomponent reactions to build high-value-added products is an important demand for organic synthesis.Herein,we detailed the successful implementatio...
关键词：Fluorine chemistry Multicomponent reactions Environmental chemistry HETEROCYCLES ENAMINONES AMIDINES 
Iron-catalyzed[4+2]annulation of amidines with α,β-unsaturated ketoxime acetates toward 2,4,6-trisubstituted pyrimidines
《Green Synthesis and Catalysis》2023年第2期150-153,共4页Qinghuan Wu Luchao Li Binyan Xu Jie Sun Dong Ji Yuguang Li Lei Shen Zheng Fang Jindian Duan Beining Chen Kai Guo 
the National Natural Science Foundation of China(No.22078150);the National Key R&D Program of China(No.2021YFC2101904);the Jiangsu Province Industrial Prospects and Key Core Technologies-Competitive Projects(No.BE2021083);the Nanjing International Joint R&D Project(No.202002037)for their financial support。
An iron-catalyzed[4+2]annulation of amidines with α,β-unsaturated ketoxime acetates is described.This strategy employs amidines as CN units and provides a new protocol for the construction of 2,4,6-trisubstituted py...
关键词：ANNULATION AMIDINES Ketoxime acetates PYRIMIDINES Iron 
Synthesis of pyrimidines from dinitrogen and carbon被引量：2
《National Science Review》2022年第12期214-220,共7页Xianghui Shi Qianru Wang Chao Qin Li-Jun Wu Yuanjin Chen Gao-Xiang Wang Yongli Cai Wenbo Gao Teng He Junnian Wei Jianping Guo Ping Chen Zhenfeng Xi 
supported by the Basic Science Center of Transformation Chemistry of Key Components of Air;the National Natural Science Foundation of China(21988101).
The element nitrogen and nitrogenous compounds are vital to life.The synthesis of nitrogen-containing compounds using dinitrogen as the nitrogen source,not through ammonia,is of great interest and great value but rema...
关键词：dinitrogen transformation nitrogen fixation N-C bond formation homogeneous-heterogeneous synergy strategy 15n-labeled pyrimidines 
One-Pot Synthesis of Pyrido[2,3-d]pyrimidines Catalyzed by Bismuth(III)Triflate
《International Journal of Organic Chemistry》2022年第1期11-27,共17页Deniz Saglam Zuhal Turgut 
Synthesis of uracil derivatives, such as pyrido[2,3-d]pyrimidine, is very important for the pharmaceutical industry due to their many biological activities. In our continuing efforts into the development of new synthe...
关键词：Bismuth Triflate Pyrido[2 3-d]pyrimidine ONE-POT Biological Activity 
Synthesis and Antibacterial Activities of New 2-(Benzylthio)pyrimidines and 2-(Benzimidazolylmethylthio)pyrimidines Derivatives
《Open Journal of Medicinal Chemistry》2021年第3期27-39,共13页Achi Patrick-Armand Coulibali Siomenan Zon Doumade Timotou Adéyolé Bolou Eric Touré Daouda Sissouma Drissa Adjou Ané 
A series of 2-(benzylthio)
《Chinese Chemical Letters》2020年第5期1281-1287,共7页Xianglong Hu Qiuju Xun Tao Zhang Su-Jie Zhu Qian Li Linjiang Tong Mengzhen Lai Tao Huang Cai-Hong Yun Hua Xie Ke Ding Xiaoyun Lu 
financial support from the National Natural Science Foundation of China(Nos.81922062,81874285 and 81673285);Guangdong International Science and TechnologyCooperation Project(No.2018A050506043);Guangzhou City Key Laboratory of Precision Chemical Drug Development(No.201805010007);Institutes for Drug Discovery and Development of Chinese Academy of Science(No.CASIMM0120185006)。
Extensive structure-activity relationships(SARs)study of JND3229 was conducted to yield a series of new reve rsible 2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidine privileged scaffold as EGFRC797 S inhibitors.One of the mo...
关键词：EGFRC797S mutant SARs 2-Oxo-3 4-dihydropyrimido[4 5-d] PYRIMIDINE Clinical resistance Fourth-generation inhibitors 
Nucleosides 10: Synthesis of New Derivatives of Pyrimidine and Fused Pyrimidine Nucleosides of Expected Biological Activity
《International Journal of Organic Chemistry》2019年第3期107-120,共14页Laila M. Break Mosselhi A. M. Mohamed Ohoud A. A. Al-Thubaiti Fatma E. M. Eibaih 
Pyrimidines, such as 6-amino-2-thio and 2-methylthiouracils and fused pyrimidines, such as thienopyrimidines reacted with 1-O-acetyl-2,3,5-tri-O- benzoyl-β-D-ribofuranose to get new derivatives of the corresponding n...
关键词：Synthesis NUCLEOSIDES PYRIMIDINES FUSED PYRIMIDINES HETEROCYCLES Biological Activity 
Molecular Docking, 3D-QSAR and Molecular Dynamics Simulation Studies of Substituted Pyrimidines as Selective Covalent Janus Kinase 3 Inhibitors被引量：2
《Chinese Journal of Structural Chemistry》2018年第6期839-853,共15页蔡晓力 马玉卓 赵钟祥 张玲 刘鹰翔 
supported by the National Natural Science Foundation of China(No.81270054);the program for Outstanding Young Teachers in Higher Education Institutions of Guangdong Province(No.Yq2013045)
Janus kinase 3（JAK3） is a member of Janus kinase（JAK） family, and it represents a promising target for the treatment of immune diseases and cancers. However, no highly selective inhibitors of JAK3 have been develo...
关键词：JAK3 molecular docking 3D-QSAR molecular dynamics simulations binding free energy 
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