Central serous chorioretinopathy:from glucocorticoids to light intensity  

作　　者：Amir Norouzpour Majid Abrishami 

机构地区：[1]Eye Research Center, Khatam-A1-Anbia Eye Hospital,Mashhad University of Medical Sciences, Mashhad 91959-65919, Iran [2]Retina Research Center, Khatam-A1-Anbia Eye Hospital,Mashhad University of Medical Sciences, Mashhad 91959-65919, Iran

出　　处：《International Journal of Ophthalmology(English edition)》2016年第2期312-314,共3页国际眼科杂志（英文版）

摘　　要：Central serous chorioretinopathy （CSC） is characterized by a localized accumulation of subretinal fluid and an idiopathic focal leakage from choroidal vessels. The exact pathogenesis of CSC, however, still remains obscure. In this paper, we hypothesized that CSC may result from a response of choroidal vessels to an acute increase in the environmental light intensity leading to a focal leakage from the choroidal vessels. High levels of glucocorticoids, in our proposed model, may cause persistence rather than initiation of the focal leakage, probably by suppressing the synthesis of collagen and extracellular matrix components and inhibiting fibroblastic activity.Central serous chorioretinopathy （CSC） is characterized by a localized accumulation of subretinal fluid and an idiopathic focal leakage from choroidal vessels. The exact pathogenesis of CSC, however, still remains obscure. In this paper, we hypothesized that CSC may result from a response of choroidal vessels to an acute increase in the environmental light intensity leading to a focal leakage from the choroidal vessels. High levels of glucocorticoids, in our proposed model, may cause persistence rather than initiation of the focal leakage, probably by suppressing the synthesis of collagen and extracellular matrix components and inhibiting fibroblastic activity.

关 键 词：central serous chorioretinopathy GLUCOCORTICOIDS light intensity TEMPERATURE choroidal vessels 

分 类 号：R774.1[医药卫生—眼科]