Cystine oligomers successfully attached to peptide cysteine- rich fibrils  

作　　者：Christian Bortolini Mingdong Dong 

机构地区：[1]Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus C 8000, Denmark

出　　处：《Frontiers of Chemical Science and Engineering》2016年第1期99-102,共4页化学科学与工程前沿（英文版）

摘　　要：Amyloid peptides are renowned to be related to neurodegenerative diseases, however, a fruitful avenue is to employ them as high-performance nanomaterials. These materials benefit from the intrinsic outstanding mechanical robustness of the amyloid backbone made of r-strands. In this work, we exploited amyloid-like fibrils as functional material to attach pristine L-cysteine aggregates （cystine oligomers） and gold nanoparticles, without the need of templating compounds. This work will open new avenues on functional materials design and their realisation.Amyloid peptides are renowned to be related to neurodegenerative diseases, however, a fruitful avenue is to employ them as high-performance nanomaterials. These materials benefit from the intrinsic outstanding mechanical robustness of the amyloid backbone made of r-strands. In this work, we exploited amyloid-like fibrils as functional material to attach pristine L-cysteine aggregates （cystine oligomers） and gold nanoparticles, without the need of templating compounds. This work will open new avenues on functional materials design and their realisation.

关 键 词：CYSTEINE peptide fibrils gold nanoparticles AMYLOIDS OLIGOMERS nanomaterials 

分 类 号：TQ464.7[化学工程—制药化工] O63[理学—高分子化学]