Antioxidant and antitumor effects and immunomodulatory activities of crude and purified polyphenol extract from blueberries  

作　　者：Xiaohong Kou Lihua Han Xingyuan Li Zhaohui Xue Fengjuan Zhou 

机构地区：[1]School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China [2]Sinograin Oil (Tianjin) Corp., Tianjin 300461, China

出　　处：《Frontiers of Chemical Science and Engineering》2016年第1期108-119,共12页化学科学与工程前沿（英文版）

摘　　要：The antioxidant and antitumor effects as well as the immunomodulatory activities of crude and purified polyphenol extract from blueberries were investigated. The antioxidant and antitumor effects of the polyphenol extract were measured both in vitro and in vivo, and their effect on the immune systems of CD-1 tumor-bearing mice were also analyzed. In vitro assays demonstrated that blueberry purified polyphenol extract （BBPP） exhibited higher antioxidant activities than blueberry crude polyphenol extract （BBCP）, but the opposite effect was observed in vivo. Both the in vitro and in vivo antitumor activity and the immunity assay showed that BBCP not only inhibited tumor growth, but also significantly improved the immunity of the mice. According to physical and histological studies, the CD-1 tumor-bearing mice treated with the polyphenol extract, especially high doses of BBCP experienced a higher quality of life than the positive control group （treated with cyclophosphamide）. These results indicate that BBCP has significant antioxidant and antitumor activities and that it can enhance the immunity of CD-1 tumor-bearing mice.The antioxidant and antitumor effects as well as the immunomodulatory activities of crude and purified polyphenol extract from blueberries were investigated. The antioxidant and antitumor effects of the polyphenol extract were measured both in vitro and in vivo, and their effect on the immune systems of CD-1 tumor-bearing mice were also analyzed. In vitro assays demonstrated that blueberry purified polyphenol extract （BBPP） exhibited higher antioxidant activities than blueberry crude polyphenol extract （BBCP）, but the opposite effect was observed in vivo. Both the in vitro and in vivo antitumor activity and the immunity assay showed that BBCP not only inhibited tumor growth, but also significantly improved the immunity of the mice. According to physical and histological studies, the CD-1 tumor-bearing mice treated with the polyphenol extract, especially high doses of BBCP experienced a higher quality of life than the positive control group （treated with cyclophosphamide）. These results indicate that BBCP has significant antioxidant and antitumor activities and that it can enhance the immunity of CD-1 tumor-bearing mice.

关 键 词：crude polyphenol extract purified polyphenol extract BLUEBERRY ANTIOXIDANT ANTITUMOR immunity 

分 类 号：S663.2[农业科学—果树学] TQ464.1[农业科学—园艺学]