ERα和ERβ在乳腺癌组织中的表达及临床意义  

Expression of ERα and ERβ in breast cancers and their significance

作　　者：于兆进[1] 于丽凤[1] 江龙洋 毕佳[1] 林姝[1] 卫倩[1] 魏敏杰[1] 赵琳[1] 

机构地区：[1]中国医科大学药学院药理教研室,辽宁沈阳110122

出　　处：《现代肿瘤医学》2016年第9期1385-1389,共5页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81573462);辽宁省高等学校优秀人才支持计划项目(编号:LJQ2015118)

摘　　要：目的:观察ERα和ERβ蛋白表达与乳腺癌临床病理参数的相关性及临床意义。方法:收集散发性乳腺癌标本214例,乳腺纤维腺瘤组织25例,应用SP免疫组化法检测ERα和ERβ蛋白的表达情况,并分析与乳腺癌患者临床指标及病理参数的相关性。结果:乳腺癌中ERα、ERβ蛋白表达阳性率分别为56.5%(121/214)、62.1%(133/214),乳腺纤维腺瘤中ERα、ERβ蛋白表达阳性率分别76.0%(19/25)、84.0%(21/25),与乳腺纤维腺瘤组织比较,乳腺癌组织ERα蛋白阳性表达率无差异,ERβ蛋白阳性表达率显著低于乳腺纤维腺瘤组织(P=0.031)。在乳腺癌组织中,ERα蛋白表达水平与患者年龄、病理类型、临床分级及淋巴结转移、HER-2、p53蛋白表达均未见相关性,与PR蛋白表达正相关(P<0.000 1)。ERβ蛋白表达与患者年龄和绝经状态相关,在不同的病理类型中,浸润性小叶癌的ERβ蛋白表达阳性率明显高于其它类型肿瘤(P=0.029);ERβ蛋白表达与临床分级、淋巴结转移情况、HER-2、p53蛋白表达比较均未见相关性。生存分析发现,ERα和ERβ蛋白表达对乳腺癌患者总体生存期未见显著影响,ERα和ERβ均阳性表达的乳腺癌患者,OS时间明显延长(P<0.05)。结论:ERα、ERβ蛋白在乳腺癌组织的异常表达与患者年龄、绝经状态、病理类型相关,二者协同表达对于乳腺癌的发生和发展更具指导意义。Objective：To study the con＇elation of ERα and ERβ expression with clinicalpathological parameters in breast cancer. Methods：ERa and ERβ protein expression were detected in 214 cases of sporadic breast cancers and 25 cases of breast fibroadenoma tissues using immunohistochemistry（Sp method）. The con＇elations of ERα and ERβ with the clinicalpathological parameters were analyzed. Results：The positive immunostaining rate of ERα, ERβ in breast cancer were 56.5% （121/214） ,62.1% （ 133/214）, the positive immunostaining rate of ERa, ER in fibroadenoma tissues were 76.0% （19/25） ,84.0% （21/25）. There was no significant difference of ER protein expression in breast carcinoma samples compared with benign breast hypeqolasia. The positive immunostaining rate of ERβ was significant lower than that in fibroadenoma tissues （ 84.0 % vs 62.1% , P = 0.031 ）. There was positively con＇elation between ERα and ERβ expression（P 〈 0. 000 1 ）. The expression of ERα in breast cancer tissues was related to PR and was not associated with histological types, age, menopause status, clinical stage,lymph node metastases state, p5 3 and HER - 2 expression. It was significantly lower in ERβ positive pro - menopause patients （71.2% vs 49.7% ,P = 0. 004）. Among different histologic type, 86.4% infiltrating lobular carcinoma showed ERβ positive higher than other histologic type tumors. In contrast, no correlation was found between the ERβ positive and tumor size, clinical stage lymph node metastases state, p53 and HER -2 expression. The survival analysis showed that the expression of ERα and ERβ protein in breast cancer patients had no significant effect on the overall survival time. However, patients with ERα and ERβ co -expression had longer OS time （P 〈 0.05 ）. Conclusion：The abnormal expression of ERβprotein in breast cancer tissues was correlated with age, menopausal status and pathological type of breast cancer, and the co - expression of the ERα and ERβ was more importa

关 键 词：散发性乳腺癌 ERΑ ERΒ 预后 

分 类 号：R737.9[医药卫生—肿瘤]