中国南方汉族人群CYBA基因C242T多态性与精神分裂症的关联  

Association of the CYBA gene C242T polymorphism with schizophrenia in Southern Chinese population

作　　者：罗旭东[1] 林举达[1] 梁爱萍[2] 邹晓波[1] 陈武标[3] 

机构地区：[1]广东省湛江市广东医学院附属医院精神心理科,524001 [2]广东省湛江市广东医学院附属医院血透中心524001 [3]广东省湛江市广东医学院附属医院放射科,524001

出　　处：《神经疾病与精神卫生》2016年第1期70-72,共3页Journal of Neuroscience and Mental Health

基　　金：湛江市财政资金科技专项备用经费项目（2014C01024）;湛江市非资助科技攻关计划项目（2013801221）

摘　　要：目的探讨中国南方汉族人群NADPH氧化酶p22phox亚基基因（CYBA）C242T多态性和精神分裂症的易感性及疾病严重程度的关联。方法本研究利用SNaPshot技术对906例中国南方汉族人群精神分裂症患者和982名健康对照者进行CYBA基因C242T多态性检测，采用阳性与阴性症状量表（PANSS）对患者组进行精神症状严重程度评定。结果（1）CYBA基因C242T多态性位点基因型频率和等位基因频率在精神分裂症患者和健康人群中的分布差异无统计学意义（P〉0．05）；（2）C242T多态性位点CT＋TT基因型患者PANsS量表的阴性量表分及总分高于CC基因型患者（P〈0．05）。结论CYBA基因C242T多态性与中国南方汉族精神分裂症的易感性无明显关联，C242T多态性位点T突变可能会加重精神分裂症患者的阴性症状。Objective To investigate the potential association between the C242T polymorphism of CYBA gene and risk, severity of schizophrenia. Methods Multiplex SNaPshot was used to determine the genotype and allele frequencies of CYBA gene C242T in 906 schizophrenic patients and 982 controls. Psychotic symptoms were evaluated in accordance with structured interv, iew for the Positive and Negative Symptom Scale （PANSS）. Results （1） There were no significant differences in genotype and allele fre- quencies for C242T polymorphism between the cases and controls （P 〉 0.05）. （2）The C242T polymor- phism C/T and T/T carriers had higher negative symptom scores and total scores than C/C carriers （P 0.05）. Conclusions There were no association between the C242T polymorphism of CYBA gene and risk of schizophrenia. C242T mutation of T may aggravate the negative symptoms of schizophrenia patients.

关 键 词：精神分裂症 NADPH氧化酶 CYBA 多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]