Rheb的功能及其在血液肿瘤中的作用研究进展  

Recent Studies on Functions of Rheb and Its Role in Hematological Malignancies

作　　者：高亚男[1] 程涛[1] 袁卫平[1] 

机构地区：[1]中国医学科学院北京协和医学院血液学研究所血液病医院实验血液学国家重点实验室,天津300020

出　　处：《医学综述》2016年第6期1102-1106,共5页Medical Recapitulate

基　　金：科技部973国家重点基础研究发展计划项目(2012CB966604);国家自然科学基金(81470280;81421002;81328003)

摘　　要：Rheb为GTP结合蛋白,可调控细胞的生长、增殖、凋亡、存活以及自噬等细胞的基本生命活动,其与结节性硬化症和某些肿瘤相关。Rheb可调控造血干祖细胞的功能,其过表达可促进淋巴瘤生成,在白血病中可检测到Rheb的过表达。法尼基转移酶抑制剂是Rheb的抑制剂,可通过促进白血病细胞凋亡,抑制白血病进展。此外,法尼基转移酶抑制剂已在血液恶性疾病中进行了Ⅱ/Ⅲ期临床试验,有可能作为药物用于临床。Rheb is a GTP binding protein,which plays an important role in regulating many cellular processes such as cell growth,proliferation,apoptosis,survival,autophagy and so on. It has been demonstrated that Rheb is related to tuberous sclerosis and some tumors. Rheb has been demonstrated to play a role in regulating hematopoietic stem and progenitor cells,and generating lymphoma. Rheb overexpression was found in leukemia. Farnesyltransferase inhibitors（ FTIs）,as Rheb inhibitors,inhibit leukemia progression via promoting leukemia cell apoptosis. FTIs have been used in phase Ⅱ / Ⅲ clinical trials in patients with hematological malignancies,which suggested that Rheb could be a potential therapeutic drug for clinical use.

关 键 词：RHEB 白血病 淋巴瘤 正常造血 

分 类 号：R730.2[医药卫生—肿瘤]