Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele  

作　　者：Mariana Camargo Paula Intasqui Ricardo Pimenta Bertolla 

机构地区：[1]Department of Surgery, Division of Urology, Human Reproduction Section, Sao Paulo Federal University, R. Embau, 231, 04039-060, Sao Paulo, Brazil [2]Sao Paulo Hospital, Sao Paulo, Brazil.

出　　处：《Asian Journal of Andrology》2016年第2期194-201,J0003,共9页亚洲男性学杂志（英文版）

摘　　要：Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a ＂silent＂ varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome.Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a ＂silent＂ varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome.

关 键 词：male infertility PROTEOMICS seminal plasma VARICOCELE VARICOCELECTOMY 

分 类 号：R0[医药卫生]