经典Wnt信号通路对骨代谢的调节作用  

The regulatory role of classic Wnt signaling pathway in bone metabolism

作　　者：徐伟丽[1] 牛玲玲[1] 王文侠[2] 崔鹏举[1] 

机构地区：[1]哈尔滨工业大学化工学院食品科学系,哈尔滨150090 [2]齐齐哈尔大学食品与生物工程学院黑龙江省普通高校农产品加工重点实验室,齐齐哈尔161006

出　　处：《中国骨质疏松杂志》2016年第3期376-380,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(31501481);黑龙江省自然科学基金(B201115);2013年黑龙江省博士后科研启动金资助(LBHQ13086)

摘　　要：Wnt信号通路是一个调控细胞生长、发育和分化的重要信号途径。越来越多的证据表明,经典Wnt信号通路在成骨细胞的分化进程及骨形成过程中扮演着重要角色。本文就经典Wnt信号通路中已知的与骨代谢相关的各个成分及其功能,以及对通过Wnt信号通路防治骨质疏松的研究进展进行了综述,以期能为相关骨代谢性疾病的预防和治疗提供新的思路。Wht signaling pathways are important in regulating the growth,development and differentiation of cells.In recent years,a large number of studies showthat the classic Wnt pathway has been shown to play a huge role in the control of osteoblastogenesis and bone formation.In the present reviewwe summarized the current knowledge related to the elements and the known functions of the classic Wnt signaling system in order to further study the classical Wnt pathway of osteoblasts.We also conducted preliminary discussion on the prevention and treatment of osteoporosis through the Wnt signaling pathways,finally developing a newstrategy in the prevention and treatment of osteoporosis.

关 键 词：WNT通路 因子 成骨细胞 骨质疏松 

分 类 号：R336[医药卫生—人体生理学]