MSCs来源的外泌体修复组织损伤的机制研究进展  

RESEARCH PROGRESS OF MECHANISMS OF MESENCHYMAL STEM CELLSDERIVED EXOSOMES IN TISSUE REPAIR

作　　者：张国威[1,2] 汪泱[3] 邓志锋[2] 

机构地区：[1]泰山医学院,山东泰安271000 [2]上海交通大学附属第六人民医院神经外科 [3]上海交通大学附属第六人民医院四肢显微外科研究所

出　　处：《中国修复重建外科杂志》2016年第4期499-503,共5页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的对MSCs来源的外泌体（MSCs-derived exosomes,MEX）所含生物活性物质促进组织损伤修复机制进行综述,并分析其临床应用前景。方法广泛查阅近年来国内外MEX与组织修复相关的文献,并进行分析和总结。结果外泌体是直径为30-100 nm的小囊泡,包含多种生物活性物质,如m RNA、微小RNA和蛋白质等。MEX包含的多种生物活性物质是发挥修复多种组织器官损伤效应的基础,但其发挥修复效应的大多数具体生物活性分子仍未明确。结论 MEX包含的生物活性物质在组织损伤中具有修复作用,为临床治疗组织损伤提供了新思路;但MEX的个体差异性及可能加快癌症进展的风险尚需深入研究。Objective To review the mechanisms of bioactive substances of mesenchymal stem cells-derived exosomes（MEX） in tissue repair and analyze the therapeutic values of MEX. Methods Recent relevant literature about MEX for tissue repair was extensively reviewed and analyzed. Results The diameter of exosomes ranges from 30 to 100 nm which contain an abundance of bioactive substances, such as m RNA, micro RNA, and protein. The majority of the exact bioactive substances in MEX, which are therapeutically beneficial to a wide range of diseases, are still unclear. Conclusion Bioactive substances contained in the MEX have repairing effect in tissue injury, which could provide a new insight for the clinical treatment of tissue damage. However, further studies are required to investigate the individual differences of MEX and the possible risk of accelerating cancer progression of MEX.

关 键 词：MSCS 外泌体 生物活性物质 组织修复 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]