1341例羊水细胞染色体核型的产前诊断指征评价  

Evaluation of prenatal diagnosis indicators among 1341 cases of amniotic fluid cells chromosomal karyotypes

作　　者：蔡素清[1] 郭正琴[1] 李朝晖[1] 

机构地区：[1]福建医科大学附属闽东医院,闽东355000

出　　处：《中国妇幼卫生杂志》2016年第2期48-50,共3页Chinese Journal of Women and Children Health

摘　　要：目的探讨不同产前诊断指征在异常羊水染色体诊断中的价值。方法取2011年1月-2014年12月在福建医科大学附属闽东医院产前诊断中心行羊水穿刺的孕妇1341例,对不同产前诊断指征的羊水细胞染色体结果进行比较,评价各指征对胎儿染色体异常的提示作用。结果 1341例羊水细胞染色体中共检出44例异常核型,血清学21-三体高风险组、血清学18-三体高风险组、高龄组、彩超异常组、其他因素组检出率分别为3.07、25.81、1.07、11.11、4.54%。结论对于血清学21-三体、18-三体高风险组应行羊水染色体检查,而单纯高龄也可先行血清学筛查,并重视孕期彩超筛查。Objective To explore the value of different prenatal diagnosis indicators in diagnosis of abnormal amniotic fluid cells chromosomal karyotypes. Methods From January 2011 to December 2014,1341 cases carried out amniocentesis in the Prenatal Diagnosis Center of Ming Dong Hospital. Karyotypes of amniotic fluid cells with different indicators were compared and analyzed;predictive function of indicators for fetal chromosomal abnormalities was evaluated. Results Among the 1341 cases,44 cases of abnormal karyotypes were detected. The detection rates of high risk for trisomy 21,high risk for trisomy 18,maternal high age group、ultrasound screening abnormal group and other reasons group was 3. 07%（ 27 /879）,25. 81%（ 8 /31）,1. 07%（ 4 /373）,11. 11%（ 4 /36）,4. 54%（ 1 /22） respectively. Conclusion It is necessary to check fluid chromosomal karyotypes in high risk for trisomy 21 and trisomy 18,however,simple maternal high age group also can do serum screening first and value ultrasound screening in pregnant.

关 键 词：产前诊断 羊水细胞 染色体核型 

分 类 号：R714.5[医药卫生—妇产科学]