大黄酚复合物的制备方法研究  

Preparation of Inclusion Complex of Chrysophanol

作　　者：李红 吴振[2] 陈岗[2] 詹永[2] 谭红军[2] 

机构地区：[1]重庆市食品药品检验检测研究院,重庆401121 [2]重庆市中药研究院,重庆400065

出　　处：《天然产物研究与开发》2016年第4期575-578,共4页Natural Product Research and Development

基　　金：重庆市卫生局中医药科研课题(ZY20132075);重庆市基本科研业务费资助项目(JA-15-14);重庆市基本科研业务费资助项目(2015cstc-jbty-01911)

摘　　要：为提高大黄酚(Chr)的水溶性和生物利用度,旨在找出一种适合大黄酚-β-葡聚糖超分子复合物(Chr-β-glu)的制备方法,为制剂加工和贮存研究提供依据。分别采用饱和溶液法、共研磨法、冷冻干燥法、电磁搅拌-喷雾干燥法(ES)和共沉淀法等方法制备Chr-β-glu,以包封率、渗漏率和累积释放率为评价指标,选出最适合Chr-β-glu的制备方法。电磁搅拌-喷雾干燥法处理可以显著提高大黄酚-β-葡聚糖超分子包合物的平均包封率和累积释放率,明显优于其他方法;共沉淀法制备的Chr-β-glu的平均渗漏率最低,但与ES法制备相比没有显著性差异。采用电磁搅拌-喷雾干燥法制备的大黄酚-β-葡聚糖超分子包合物具有较高的包封率和稳定性,作为药物载体,其在医药、食品和日化工业中具有广泛的应用前景。To improve the solubility and bioavailability of chrsophanol（ Chr） and provide the foundation for preparation,processing and storage of new formulations,five preparation methods of supermolecular inclusion complex of Chr and β-glucan（ Chr-β-glu） were compared. The inclusion complex of Chr-β-glu prepared by saturated solution method,co-grinding method,freeze drying method,electromagnetic stirring-spray drying（ ES） method and co-precipitation method,respectively,was compared based on the index of encapsulation efficiency,percolation rate and cumulative release rate. The results showed that the encapsulation efficiency and cumulative release rate of Chr-β-glu prepared by ES method was higher than samples prepared by other preparation methods. The percolation rate of Chr-β-glu prepared by co-precipitation method was lower than samples prepared by other preparation methods. However,the percolation rate was of no significant difference between ES method and co-precipitation method. The supermolecular inclusion complex of Chr and β-glucan had higher encapsulation efficiency and better stability. It will be widely applied in medicinal,food and daily chemical industries.

关 键 词：大黄酚 葡聚糖超分子复合物 制备方法 电磁搅拌-喷雾干燥法 包封率 

分 类 号：R932[医药卫生—生药学] TS201.2[医药卫生—药学]