靶向Wnt/β-catenin信号通路抑制剂研究进展  

Research Progress of Targeted Wnt/β-catenin Signaling Pathway Inhibitors

作　　者：于彩云[1,2] 刘重慧 魏涛[1,2] 

机构地区：[1]北京联合大学应用文理学院 [2]生物活性物质与功能食品北京市重点实验室,北京100191

出　　处：《河南师范大学学报（自然科学版）》2016年第2期125-130,共6页Journal of Henan Normal University(Natural Science Edition)

基　　金：北京联合大学生物活性物质与功能食品北京市重点实验室开放课题(ZK70201405)

摘　　要：Wnt/β-catenin信号通路高度复杂,与Notch通路、Hedgehog通路等都有密切联系,参与机体胚胎发育、调控生物体细胞增殖、代谢等多个方面.研究发现,该信号通路的异常激活与肿瘤密切相关.据汤森路透数据库统计发现,截至2014-04-24,共报道Wnt信号通路抑制剂228个,主要分为受体抑制剂和胞内小分子抑制剂等.本文综述了Wnt/β-catenin信号通路抑制剂及其调控机制,旨在为肿瘤预防与治疗提供新素材.Wnt/β-catenin signaling pathway is highly complex,and has a close relationship with Notch pathway,Hedgehog pathway and so on.It is involved in the development of organism,the proliferation and metabolism of biological cells.It is found that the abnormal activation of the signal pathway is closely related to tumor.According to Thomson Reuters database,as of April 24,2014,a total of 228 inhibitors of Wnt signaling pathway were reported,which were mainly divided into receptor inhibitors and intracellular small molecule inhibitors.In this paper,we reviewed the Wnt/-catenin signaling pathway inhibitor and its regulation mechanism,which aims to provide new material for tumor prevention and treatment.

关 键 词：WNT/Β-CATENIN信号通路 受体抑制剂 小分子抑制剂 

分 类 号：R730.54[医药卫生—肿瘤]