弹性蛋白和Ⅰ型胶原α2基因多态性与颅内动脉瘤  

Polymorphisms of elastin and collagen type Ⅰ α2 genes and intracranial aneurysm rupture

作　　者：聂小娟[1] 张京芬[2] 

机构地区：[1]内蒙古医科大学研究生院,呼和浩特010110 [2]包头市中心医院神经内科,014040

出　　处：《国际脑血管病杂志》2016年第3期272-274,共3页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(81460189) Fund program:National Natural Science Foundation of China

摘　　要：颅内动脉瘤主要由动脉管壁局部缺陷和管腔内压力增高所致。未破裂的小动脉瘤一般无症状,而破裂动脉瘤则可引起蛛网膜下腔出血（subarachnoid hemorrhage, SAH）。颅内动脉瘤的病因和发病机制迄今尚不完全清楚。大量证据表明,颅内动脉瘤是环境因素与多基因共同作用的复杂性疾病。文章对弹性蛋白（elastin, ELN）和Ⅰ型胶原α2（colagen type Ⅰα2, COL1A2）基因多态性与颅内动脉瘤的联系进行了综述。Intracranial aneurysms are mainly caused by the local arterial wal defects and the increased intraluminal pressure. Usualy, the unruptured smal aneurysms are asymptomatic, and the ruptured aneurysms can cause subarachnoid hemorrhage. So far, the etiology and pathogenesis of intracranial aneurysms are not fuly understood. A lot of evidence has showed that intracranial aneurysms are a complex disease of environmental factors and multi-gene interaction. This article reviews the correlation between polymorphisms of elastin and colagen type Ⅰ α2 genes and intracranial aneurysm.

关 键 词：颅内动脉瘤 蛛网膜下腔出血 多态现象  遗传学 弹性蛋白 胶原Ⅰ型 Colagen Type Ⅰ 

分 类 号：R743[医药卫生—神经病学与精神病学]