氧化代谢酶DNA甲基化研究进展  

DNA methylation of oxidative metabolic enzymes:research progres

作　　者：周思园[1] 胡建安[1] 黄璨[2] 

机构地区：[1]中南大学公共卫生学院劳动卫生与环境卫生学系,湖南长沙410078 [2]中南大学公共卫生学院流行病学与卫生统计学系,湖南长沙410078

出　　处：《中国药理学与毒理学杂志》2016年第4期405-414,共10页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81072331)~~

摘　　要：DNA甲基化是表观遗传修饰过程之一,能导致基因表达异常。细胞色素P450酶、环氧合酶、脂氧合酶和单胺氧化酶是人体内介导内外源化学物氧化代谢的酶类,这些酶基因在正常组织与病理组织中的甲基化模式存在差异,异常的甲基化模式会导致酶表达和功能发生改变,进而影响疾病的发生和发展。本文就上述4种氧化代谢酶基因甲基化状态在一些疾病组织中的特征性变化、对化学物的代谢活性的影响以及对机体的作用变化进行综述,为疾病的诊断以及化学物毒作用机制提供新的理论依据。DNA methylation is part of the epigenetic modification process,which can lead to aberrant gene expression. Cytochrome P450 enzyme,cyclooxygenase,lipoxygenase and monoamine oxidase are a class of enzymes produced by human tissues,which are involved in the oxidization process of endogenous and exogenous chemicals. The methylation patterns of these enzyme genes are different between normal tissues and pathological ones. Abnormal methylation patterns will change enzymes′ expression and function,and affect the occurrence and development of diseases. This paper reviewed the characteristic changes of four oxidative metabolic enzyme genes in certain diseased tissues,the impact on methylation status of the metabolic activity of chemicals and on human health. It is hoped that this review can provide a new theoretical basis for the study on the toxic mechanism of chemicals and for diagnosis of diseases.

关 键 词：DNA甲基化 细胞色素P450酶系统 脂氧合酶 环氧合酶2 单胺氧化酶 

分 类 号：R363[医药卫生—病理学]