帕金森病与核仁应激  

Parkinson＇s disease and nucleolar stress

作　　者：周青青[1] 陈永平[1] 魏倩倩[1] 商慧芳[1] 

机构地区：[1]四川大学华西医院神经内科,成都610041

出　　处：《中华医学遗传学杂志》2016年第3期392-395,共4页Chinese Journal of Medical Genetics

摘　　要：帕金森病（Parkinson’s disease，PD）是中老年人常见的神经系统变性疾病，以静止性震颤、肌强直、运动迟缓、姿势步态异常等为主要表现，其病理特征主要是中脑黑质（substantia nigra，SN）的多巴胺能神经元（dopaminergic neurons，DA）进行性丢失。核糖体RNA（rRNA）的转录下调是在应激状态下维持细胞稳态的主要方式。核仁应激即核仁的结构和功能的破坏，是变性疾病过程中新近发现的改变。近期研究表明PD患者对应激状态的反应及其调节机制受损，而代谢应激可能是PD的一种诱发机制。本文我们就PD与核仁应激的关系及机制进行综述。Parkinson＇ s disease （PD） is a common age-related neurodegenerative disorder characterized mainly by motor dysfunction resulting in bradykinesia, rigidity, tremor, gait impairment, and postural instability. The classic pathogenic feature of PD is preferential loss of dopaminergic neurons in the substantia nigra. Downregulation of rRNA transcription is one of major mechanisms to maintain cellular homeostasis under stress conditions. Nucleolar stress has emerged as a component of the degenerative process caused by impaired rRNA transcription and altered nucleolar integrity. Recent study has indicated that the response to stress conditions＇ and quality control mechanisms are impaired in PD, and that metabolic stress may be a trigger mechanism for PD. This review aims to present evidence for a role of nucleolar stress in PD and has summarized mechanisms by which nucleolar stress may play a role in the progression of PD.

关 键 词：帕金森病 核仁应激 核糖体RNA 

分 类 号：R742.5[医药卫生—神经病学与精神病学]