甲状腺髓样癌的诊治进展  

Progression of Diagnosis and Treatment of Medullary Thyroid Carcinoma

作　　者：龚艳萍[1] 刘枫[1] 邹秀和[1] 马宇[1] 苏安平[1] 雷建勇[1] 魏涛[1] 龚日祥[1] 李志辉[1] 朱精强[1] 

机构地区：[1]四川大学华西医院甲状腺乳腺外科,四川成都610041

出　　处：《中国普外基础与临床杂志》2016年第5期620-625,共6页Chinese Journal of Bases and Clinics In General Surgery

基　　金：四川省科技支撑计划项目(编号:2013SZ0041)~~

摘　　要：目的探讨甲状腺髓样癌的诊断、基因检测及治疗原则。方法复习甲状腺髓样癌诊治的相关文献及指南,并进行回顾性分析和总结。结果甲状腺髓样癌以手术治疗为主,遗传性髓样癌可以根据RET基因检测结果进行预防性甲状腺切除,晚期进展性甲状腺髓样癌可进行姑息性手术、外放射治疗或采用酪氨酸激酶抑制剂的全身性治疗。结论甲状腺髓样癌预后较差,早期易发生转移,第一次手术范围应尽量彻底,遗传性髓样癌可根据基因检测结果决定预防性手术时机,争取达到早期治愈的目的。Objective To investigate diagnosis, gene detection, and treatment principle of medullary thyroid carcinoma. Method The relevant literatures and guidelines about diagnosis and treatment of medullary thyroid carcinoma were summarized and analyzed retrospectively. Results Medullary thyroid carcinoma was given priority to surgical treatment. Hereditary medullary cancer could be prophylactic thyroidectomy by the RET gene test results. Advanced progressive medullary thyroid carcinoma, could be treated by palliative surgery, external radiotherapy, or systemic treatment with the tyrosine kinase inhibitor. Conclusions Prognosis of medullary thyroid carcinoma is worse, and occurrence of early metastasis is easy. So the first operation should be thoroughgoing. And the operation timing of prophylactic total thyroidectomy for hereditary medullary cancer could be determined by the results of RET gene detection to achieving early cure.

关 键 词：甲状腺髓样癌 诊断 基因检测 手术 治疗 

分 类 号：R736.1[医药卫生—肿瘤]