纳米材料对鼠科动物的生殖毒性及致毒机理  

Reproductive Effects and Their Mechanisms of Nanomaterials on Murine

作　　者：来子阳 胡献刚[1] 周启星[1] 

机构地区：[1]南开大学环境科学与工程学院环境污染过程与基准教育部重点实验室,天津300071

出　　处：《生态毒理学报》2016年第1期14-24,共11页Asian Journal of Ecotoxicology

基　　金：国家水专项(2012ZX07501002-001);教育部长江学者创新团队(IRT13024);国家自然科学基金(21577070;21307061);中国博士后基金(2014M550138;2015T80215)

摘　　要：纳米材料是近几年应用越来越多的一种新型材料,因此国内外科研单位对其毒性的研究也逐年增加。但是目前对鼠科动物生殖毒性及其机理的了解还相对较少,亟需大量研究填补此领域的空白。本文主要从亲代和子代2个方面阐述了纳米材料对鼠科动物的生殖毒性,从不同生物水平等方面概述了纳米材料对亲子两代鼠科动物的损伤效应及可能的机制。最后,试探性地提出了今后在纳米材料领域对鼠科动物生殖毒性的研究重点。Recently,nanomaterials as emerging materials have been applied in various fields,and their potential toxicity has attracted much attention. However,the reproductive effects and their mechanisms of nanomaterials on murine are unclear. Therefore,it is necessary to perform the relevant work to fill the gaps in knowledge. The present review elucidates the reproductive effects of nanomaterials on murine involving parents and offspring,and summarizes the potential mechanisms of toxic effects at different biotic levels. Finally,the future emphases of researches on the reproductive effects of nanomaterials were proposed.

关 键 词：纳米材料 鼠科动物 亲代 子代 生殖毒性 致毒机理 

分 类 号：X171.5[环境科学与工程—环境科学]