微生物代谢组学研究及应用进展  

Progress in Microbial Metabolomics and Its Application

作　　者：席晓敏 张和平[1] 

机构地区：[1]内蒙古农业大学乳品生物技术与工程教育部重点实验室,内蒙古呼和浩特010018

出　　处：《食品科学》2016年第11期283-289,共7页Food Science

摘　　要：代谢组学是系统生物学的重要研究领域,具有独特的优势。近年来,微生物代谢组学这一新兴领域已受到广泛的关注,它不仅提供了代谢途径的广阔图谱,而且还阐明了微生物与宿主之间的相互作用机制。本文主要阐述了微生物代谢组学研究过程中样品制备、代谢物分析鉴定以及数据分析等主要研究方法,介绍了微生物代谢组学在乳酸菌、肠道菌群、病原菌以及食品和营养学研究领域中的研究进展及其应用,并讨论了微生物代谢组学中的主要问题和发展趋势。Metabolomics is a significant research field of system biology with unique advantages. Recently, microbial metabolomics has gained much attention. It not only offers a broad picture of metabolic pathways, but also elaborates the mechanisms of the interaction between microbes and their hosts. This article summarizes the major methods involved in the research process of microbial metabolomics, including sampling preparation, analysis, metabolite identification and data analysis. Besides, this review also introduces the development and application of microbial metabolomics in research on lactic acid bacteria, the gut microbiota, pathogens, food science and nutrition. Moreover, we discuss the major issues and future trends in microbial metabolomics.

关 键 词：微生物 代谢组学 研究方法 应用 

分 类 号：TS201.3[轻工技术与工程—食品科学]