Demystifying Mechanosensitive Piezo Ion Channels  

作　　者：X.Z.Shawn Xu 

机构地区：[1]Life Sciences Institute and Department of Molecular and Integrative Physiology,University of Michigan

出　　处：《Neuroscience Bulletin》2016年第3期307-309,共3页神经科学通报（英文版）

摘　　要：Mechanosensitive channels mediate touch,hearing,proprioception,and blood pressure regulation.Piezo proteins,including Piezo1 and Piezo2,represent a new class of mechanosensitive channels that have been reported to play key roles in most,if not all,of these modalities.The structural architecture and molecular mechanisms by which Piezos act as mechanosensitive channels,however,remain mysterious.Two new studies have now provided critical insights into the atomic structure and molecular basis of the ion permeation and mechano-gating properties of the Piezo1 channel.Mechanosensitive channels mediate touch,hearing,proprioception,and blood pressure regulation.Piezo proteins,including Piezo1 and Piezo2,represent a new class of mechanosensitive channels that have been reported to play key roles in most,if not all,of these modalities.The structural architecture and molecular mechanisms by which Piezos act as mechanosensitive channels,however,remain mysterious.Two new studies have now provided critical insights into the atomic structure and molecular basis of the ion permeation and mechano-gating properties of the Piezo1 channel.

关 键 词：MECHANOSENSATION MECHANOSENSORY echanotransduction MECHANICAL CRYO-EM Piezo 

分 类 号：R338.3[医药卫生—人体生理学]