1种西沙掘海绵Dysidea sp.的化学成分研究  

Study on the chemical constituents of a marine sponge Dysidea sp. collected from the Xisha Islands

作　　者：李静[1] 陈昭华[1] 翁武银[1] 张希春[1] 

机构地区：[1]集美大学食品与生物工程学院,福建厦门361021

出　　处：《中国海洋药物》2016年第3期19-25,共7页Chinese Journal of Marine Drugs

基　　金：福建省自然科学基金项目(2014J01050);福建省教育厅项目(JA13178);厦门市科技计划项目(3502Z0131152);厦门市海洋经济发展专项资金项目(13CZP003HJ05)资助

摘　　要：目的对西沙掘海绵Dysidea sp.进行化学成分研究。方法运用正相硅胶柱色谱、反相ODS柱色谱、凝胶Sephadex LH-20柱色谱以及高效液相色谱（HPLC）等多种分离手段对西沙掘海绵Dysidea sp.化学成分进行分离纯化;并通过理化性质、波谱学数据等结构信息鉴定其化合物的结构。结果从西沙掘海绵Dysidea sp.中分离鉴定了8个化合物,分别为dictyoceratinC（1）、dactyloquinone B（2）、aminoquinone（3）、dictyoceratin A（4）、dactyloquinone D（5）、dactyloquinone E（6）、（1R＊,2E,4R＊,7E,10S＊,11S＊,12R＊）-10,18-diacetoxydolabella-2,7-dien-6-one（7）和α,β-unsaturated ester（8）。结论化合物1～6和8均为首次从该属海绵中分离得到。Objective To study the chemical compositions of the marine sponge Dysidea sp.collected from the Xisha Islands.Methods The chemical constituents of the marine sponge Dysidea sp.collected from the Xisha Islands in South China Sea were chemically investigated.Normal-phase Silica gel,Sephadex LH-20,HPLC,and other chromatographic methods were employed to isolate and purify eight compounds from the marine sponge.Results Their chemical structures were identified as dictyoceratin C（1）,dactyloquinone B（2）,aminoquinone（3）,dictyoceratin A（4）,dactyloquinone D（5）,dactyloquinone E（6）,（1R＊,2E,4R＊,7E,10S＊,11S＊,12R＊）-10,18-diacetoxydolabella-2,7-dien-6-one（7）,andα,β-unsaturated ester（8）by spectroscopic analysis and comparison with the literature data.Conclusion Compounds 1~6 and 8 were isolated from the genus of Dysideafor the first time.

关 键 词：掘海绵 倍半萜醌 结构鉴定 

分 类 号：R931[医药卫生—生药学]