24个Y-STR基因座等位基因频率的群体差异分析  

Population Difference Analysis of Allele Frequencies of 24 Y-STR Loci

作　　者：朱如心[1] 刘俊宏 赵琪[1] 林源[1] 李莉[1] 

机构地区：[1]司法部司法鉴定科学技术研究所上海市法医学重点实验室上海市司法鉴定专业技术服务平台,上海200063 [2]上海市恒平司法鉴定中心,上海200070

出　　处：《法医学杂志》2016年第3期189-192,共4页Journal of Forensic Medicine

基　　金：上海市法医学重点实验室资助项目(14DZ2270800);上海市司法鉴定专业技术服务平台资助项目(16DZ2290900)

摘　　要：目的 调查华东地区汉族无关个体24个Y-STR基因座的群体遗传学多态性,比较华东汉族和广东汉族人群间的群体差异性.方法 应用GFS 24Y STR荧光检测试剂盒,对华东地区268名汉族无关个体24个Y-STR基因座进行群体遗传学分析.比较华东汉族和广东汉族人群的等位基因频率,进行群体差异分析.结果 华东地区268名汉族无关个体24个Y-STR基因座共检出235个等位基因,267种单倍型,GD值范围为0.5649~0.9668.华东汉族和广东汉族人群在DYS622、DYS552、DYS443等12个基因座的等位基因间的差异有统计学意义.结论 GFS 24Y STR荧光检测试剂盒中的Y-STR基因座具有良好的遗传多态性,可应用于父系亲缘关系鉴定.Objective To investigate the population genetic polymorphisms of 24 Y-STR loci in unrelat-ed individuals in Eastern Chinese Han population, and to compare the difference of Han group between Eastern China and Guangdong.Methods The population genetics of 24 Y-STR loci in 268 unrelated Han individuals from Eastern China were analyzed by GFS 24 Y-STR amplification kit. The allele fre-quencies in Eastern Chinese Han population were compared with the data in Guangdong Han population, and the difference analysis between two groups was performed.Results Among the 24 Y-STR loci of 268 unrelated Han individuals from Eastern China, 235 alleles and 267 haplotypes were observed. GD value ranged from 0.5649 to 0.9668. The difference between 12 loci（DYS622,DYS552,DYS443etal.） of Han population in Eastern China and in Guangdong was statistically significance.Conclusion GFS 24Y STR amplification system shows favorable polymorphisms, which can be used in patrilineal genetic relationship identification.

关 键 词：法医遗传学 多态现象 遗传 Y染色体 短串联重复序列 等位基因 

分 类 号：DF795.2[医药卫生—法医学]